Correlation between procollagen IIIP and microalbuminuria in diabetic patients with limited articular mobility syndrome before and after control of the diabetic state

This work studied the relationship between procollagen III peptide and micro-albuminuria in insulin-dependent diabetes mellitus with limited articular mobility syndrome before and after treatment. 52 patients [12 normal control] were selected; group I: 20 IDDM with hand stiffness [limited articular mobility syndrome] and group II: 20 IDDM without hand stiffness. All cases were subjected to complete history and clinical examination to exclude previous or presence of diseases and drug that may affect glucose tolerance. The results demonstrated that serum PIIIp level is raised in all diabetic patients with limited articular mobility syndrome [group I] than in nondiabetic. It was found that the role of urinary albumin excretion in both diabetic groups are significantly correlated with the duration of diabetes and it is related to poor metabolic control. From correlation study, there is a significant positive correlation between fasting blood sugar and both PIIIp and micro-albuminuria in diabetic patient [P <0.055]. There is no significant correlation between PIIIp and both micro-albuminuria and morning stiffness [p <0.05] in diabetic group

relation between obstructive jaundice, endotoxemia and renal functions

This study showed that acute renal failure is one of the commonest complications in patients with obstructive jaundice and is a major cause of death. Besides, systemic endotoxemia is the prime cause of renal failure, treatment of endotoxemia by adding oral lactulose to the preoperative prepration of patients prevents acute renal failure and improves the renal functions. Bilirubin may have no role in occurrence of renal failure in these patients, the preoperative preparation with vitamin K, systemic antibiotics, preoperative hydration and mannitol may not be edequate and the addition of an antiendotoxic agent as lactulose is highly recommended