RESUMO
Vitamin C deficiency is a common in hemodialysis patients. Evidences indicated that oxidative stress is associated with Vitamin C deficiency. Oxidative stress plays an important role in the progression of anemia, uremia and hypertension in the patients with chronic renal failure that receiving hemodialysis. The purpose of this study was to determine the vitamin C effects on systolic blood pressure, hemoglobin, hematocrit, blood urea and creatinine. In a randomized clinical trials with registry number IRCT:2387 in Emam Reza and Besat University Hospitals in 2009, fifty six hemodialysis patients who met the inclusion criteria were selected by simple randomization method. These subjects were divided in two groups randomly: The experimental group who received oral vitamin C 250 mg, three times per week until two months. The amounts of blood pressure, hemoglobin, hematocrit, blood urea and creatinine tests were compared before and after the intervention. Finally the results were analyzed statically with T test by considered P-value less than 0.05. The level of hemoglobin and blood pressure was higher in experimental compared to control not significantly. While the blood urea and creatinine was insignificantly lower after intervention. These results show a statistical significance difference due to increasing of hematocrit level by using of oral vitamin C [P<0.05]. There is association between supplementation with oral vitamin C in hemodialysis patient and systolic blood pressure, hemoglobin, hematocrit, blood urea and creatinine. Therefore further studies are needed to determine the clinical benefits of antioxidants interventions in hemodialysis patients
RESUMO
Fatigue is a debilitating symptom or side effect experienced by many patients on dialysis therapy. Fatigue has a considerable effect on quality of life in these patients. The purpose of this study was determination of the vitamin C effect on fatigue measure. We investigated 56 hemodialysis patients who complained of fatigue and admitted at Emam Reza and Besat University Hospitals in 2009. The inclusion criteria: 1]Subjects diagnosed with chronic renal failure and received regular hemodialysis treatment for at least six month, 2] Aged 18 years or older, 3] conscious alerts and oriented, 4] Without other systemic diseases causing or increasing levels of fatigue such as chronic heart, liver and pulmonary diseases, cancer, mental retardation and chronic psychological disease, 5] Ability to communicate verbally and give informed consent and participate in this study. The exclusion criteria: the patients were excluded when supplementation with vitamin c in oral or injection form and adverse reaction occurred. The patients who met the inclusion criteria were randomly and equally in number assigned to Case and Control Groups. Case group members received oral vitamin C for two month, 250 mg, three times per week. The patients conducted fatigue severity questionnaires before and after of intervention. The results were statistically analyzed with T-test and P-value under 0.05. The fatigue score of the patients in the case group before intervention was 5.29 and after it were 3.94 while in the control group, the fatigue score of the patients were 5.007 and 4.93 before and after of intervention respectively. These results shows a statistical significance in decrease of fatigue score with [P<0.05] by using of oral vitamin C. We thing that the oral vitamin C in hemodialysis patient who complaint of fatigue is helpful