Oral mucocele exhibiting an extraoral swelling: a case report of an atypical presentation / Mucocele oral exibindo edema extraoral: relato de caso atípico

ABSTRACT Despite being common pathological entities found in the oral cavity, oral mucoceles can present distinct features, raising several diagnostic possibilities and treatments. In this study, we report the case of a 34-year-old man with an asymptomatic increased volume in the left periorbital region of more than a year, without remission or associated trauma. An aspiration biopsy was performed, followed by an excisional biopsy, and the specimen was sent for histopathological examination. Results led to the diagnosis of an oral mucocele. Surgical removal was performed in an excisional biopsy. Subsequently, the patient recovered promptly without further complications. Although oral mucoceles recur relatively often, its prognosis is good. This case emphasizes the importance of obtaining a detailed disease history, knowledge of its clinical features, and etiopathogenesis combined with complementary examinations to establish diagnostic hypotheses and converge on an adequate and individualized treatment plan

RESUMO Apesar de serem entidades patológicas comumente encontradas na cavidade oral, as mucoceles podem apresentar características distintas, o que pode sugerir diversas possibilidades diagnósticas e de tratamento. Paciente do gênero masculino, 34 anos, compareceu ao ambulatório com queixa de aumento de volume assintomático na região periorbitária esquerda há mais de um ano, sem remissão ou trauma associado. Foi realizada biópsia aspirativa seguida de biópsia excisional e a amostra encaminhada para exame histopatológico, que confirmou o diagnóstico de mucocele oral. O paciente evoluiu sem queixas e sem recidiva. Apesar da alta taxa de recorrência, mucoceles orais têm um bom prognóstico. Este relato de caso enfatiza a importância da obtenção de uma história detalhada da doença, do conhecimento de suas características clínicas e da etiopatogenia, para estabelecer hipóteses diagnósticas e convergir para um plano de tratamento adequado e individualizado.

Bioactive glass-ceramic for bone tissue engineering: an in vitro and in vivo study focusing on osteoclasts

Abstract: Despite the crucial role of osteoclasts in the physiological process of bone repair, most bone tissue engineering strategies have focused on osteoblast-biomaterial interactions. Although Biosilicate® with two crystalline phases (BioS-2P) exhibits osteogenic properties and significant bone formation, its effects on osteoclasts are unknown. This study aimed to investigate the in vitro and in vivo effects of BioS-2P on osteoclast differentiation and activity. RAW 264.7 cells were cultured in osteoclastogenic medium (OCM) or OCM conditioned with BioS-2P (OCM-BioS-2P), and the cell morphology, viability, and osteoclast differentiation were evaluated. BioS-2P scaffolds were implanted into rat calvarial defects, and the bone tissue was evaluated using tartrate-resistant acid phosphatase (TRAP) staining and RT-polymerase chain reaction (PCR) after 2 and 4 weeks to determine the gene expressions of osteoclast markers and compare them with those of the bone grown in empty defects (Control). OCM-BioS-2P favored osteoclast viability and activity, as evidenced by an increase in the TRAP-positive cells and matrix resorption. The bone tissue grown on BioS-2P scaffolds exhibited higher expression of the osteoclast marker genes (Ctsk, Mmp 9, Rank) after 2 and 4 weeks and the RankL/Opg ratio after 2 weeks. Trap gene expression was lower at 2 weeks, and a higher number of TRAP-stained areas were observed in the newly formed bone on BioS-2P scaffolds at both 2 and 4 weeks compared to the Controls. These results enhanced our understanding of the role of bioactive glass-ceramics in bone repair, and highlighted their role in the modulation of osteoclastic activities and promotion of interactions between bone tissues and biomaterials.

Anterior lingual mandibular bone cavity: a case report / Cavidade óssea mandibular lingual anterior: um relato de caso

Stafne's bone cavity (SBC) is an asymptomatic lingual bone cavity situated near the angle of the mandible. The anterior variant of SBC, which shows a radiolucent unilateral ovoid lingual bone concavity in the canine-premolar mandibular region, is uncommon. A 73-year-old man was referred for assessment of loss of mandibular bone. Panoramic radiographs and computerized tomography scans showed a well-defined lingual bony defect in the anterior mandible. Analysis of imaginological documentation, made 14 years ago, revealed a progressive increase in mesiodistal diameter and intraosseous bony defect. The soft tissue obtained within the bony defect, microscopically revealed fibrous stroma containing blood vessels of varied caliber. The current anterior lingual mandibular bone defect case is probably caused by the salivary gland entrapped or pressure resorption, which can explain the SBC pathogenesis (AU)

A cavidade óssea de Stafne (COS) é uma cavidade assintomática, localizada próximo ao ângulo da mandíbula, por lingual. A variante anterior da COS, a qual apresenta uma concavidade óssea lingual radiolúcida, ovoide e unilateral na região do caninopré-molar mandibular, é incomum. Um homem de 73 anos foi encaminhado para avaliação da perda óssea mandibular. A radiografia panorâmica e a tomografia computadorizada mostraram um defeito ósseo lingual bem definido na região anterior da mandibula. A análise da documentação imaginológica, realizada há 14 anos, revelou um aumento progressivo do diâmetro mesiodistal e defeito ósseo intraósseo. A biópsia do tecido mole obtido do defeito ósseo revelou microscópicamente estroma fibroso contendo vasos sanguíneos de calibre variado. O presente caso de defeito ósseo mandibular na região lingual anterior é provavelmente causado por glândula salivar aprisionada ou reabsorção por pressão, o que pode explicar a patogênese da COS. (AU)

Bone tissue response to plasma-nitrided titanium implant surfaces

A current goal of dental implant research is the development of titanium (Ti) surfaces to improve osseointegration. Plasma nitriding treatments generate surfaces that favor osteoblast differentiation, a key event to the process of osteogenesis. Based on this, it is possible to hypothesize that plasma-nitrided Ti implants may positively impact osseointegration. Objective The aim of this study was to evaluate the in vivo bone response to Ti surfaces modified by plasma-nitriding treatments. Material and Methods Surface treatments consisted of 20% N2 and 80% H2, 450°C and 1.5 mbar during 1 h for planar and 3 h for hollow cathode. Untreated surface was used as control. Ten implants of each surface were placed into rabbit tibiae and 6 weeks post-implantation they were harvested for histological and histomorphometric analyses. Results Bone formation was observed in contact with all implants without statistically significant differences among the evaluated surfaces in terms of bone-to-implant contact, bone area between threads, and bone area within the mirror area. Conclusion Our results indicate that plasma nitriding treatments generate Ti implants that induce similar bone response to the untreated ones. Thus, as these treatments improve the physico-chemical properties of Ti without affecting its biocompatibility, they could be combined with modifications that favor bone formation in order to develop new implant surfaces. .

Accidental displacement of impacted maxillary third molar: a case report

Este artigo descreve um caso raro de um terceiro molar superior direito impactado que foi deslocado acidentalmente para o interior do seio maxilar durante exodontia e foi removido cirurgicamente após quase dois anos. O dente foi removido sob anestesia geral, após exposição do seio maxilar pela técnica de Caldwell-Luc. O pós-operatório transcorreu sem complicações. Seis meses após a cirurgia, houve completa recuperação do seio maxilar e a paciente não apresentou qualquer queixa.

Frey's syndrome after condylar fracture: case report

A Síndrome de Frey é compreendida como a ocorrência de hiperestesia, aumento de temperatura e suor na região da distribuição do nervo auriculotemporal e/ou nervo auricular maior, desencadeado pelo simples ato de se alimentar quando existe um grande estímulo salivatório. É também conhecida como Síndrome Auriculotemporal e Suor Gustatório. Esse artigo identifica um caso de Síndrome de Frey após fratura de côndilo mandibular que foi tratada com fixação interna rígida. Adicionalmente esta revisão da literatura detalha um teste simples (teste de Minor) que pode auxiliar no diagnostico desta síndrome.