Fibromyalgia syndrome in 104 Iraqi patients with inflammatory bowel disease

Fibromyalgia syndrome [FMS] is a common rheumatologic syndrome with multiple systemic manifestations and associated with many diseases. To assess fibromyalgia syndrome in inflammatory bowel disease. One hundred four Iraqi patients with inflammatory bowel disease were studied and compared with another [112] healthy individuals matched for age and sex as a control group. Full history was taken and complete clinical examination was done for all individuals in both groups. Fibromyalgia syndrome was diagnosed in all patients on base of the American College of Rheumatology [ACR] 1990 Criteria for the classification of FMS. Inflammatory bowel disease was detected by colonoscopy and tissue biopsy. There was a significant increase in the frequency of FMS among individuals with IBD [24%] compared to healthy control group [5.4%] [[P-value=0.0001, Odd ratio=0.18, 95% CI=0.07-0.46]. FMS occurs with increased frequency in IBD

Prevalence of fibromyalgia syndrome in patients with Haemophilia A

Fibromyalgia syndrome is a common rheumatological syndrome with multiple systemic manifestations which could occur alone or associated with many diseases. To detect the possible relation between fibromyalgia and haemophilia-A patients. One hundred patients with haemophilia-a were studied and compared with another hundred, healthy individuals matched for age and sex, serving as control group. Full history was taken and complete clinical examination was done for all individuals in both groups. The american college of rheumatology 1990 criteria for fibromyalgia were applied for both groups. They were questioned about presence of chronic widespread pain, sleep disturbance, headache fatigue and parasthesia. Detection of at least 11 of 18 tender points by digital palpation of specific soft tissue sites were needed for diagnosis of fibromyalgia. There was a significant increase in the frequency of fibromyalgia among individuals with haemophilia-a [25%] compared to healthy control group [3%] [p=0.000004, odd ratio=0.093, 95% confidence interval 0.027-0.319]. Fibromyalgia occurs with high frequency in hemophilia A patients

Cardiovascular autonomic nervous system dysfunction in Iraqi systemic lupus erythematosus patients

To assess the incidence, and pattern of autonomic dysfunction in Iraqi systemic lupus erythematosus [SLE] patients and its possible association to patient's age, duration of disease, SLE activity, drugs used and autonomic nervous system symptoms. Fifty Iraqi SLE patients and 50 healthy controls were included in this study. Full history was taken and complete clinical examination was done for all individuals in both groups. Disease characteristics [age, sex, duration, SLE disease activity index [SLEDAI], drugs used, and autonomic nervous system symptoms] were also documented. Laboratory analysis included complete blood count, general urine examination, and anti-double stranded deoxyribonucleic acid. Individuals in both groups were assessed for autonomic dysfunction using 5 non-invasive tests: heart rate response to Valsalva maneuver, heart rate response to deep breathing, and heart rate response to immediate standing [30:15 ratios], systolic blood pressure response to standing and diastolic blood pressure response to sustained handgrip. Autonomic dysfunction was categorized as normal, parasympathetic, sympathetic, and mixed pattern according to criteria proposed by Ewing. Forty three [86%] Iraqi SLE patients have autonomic dysfunction compared with 0% of controls [p=0.00000000001] and the most common autonomic function pattern was the mixed pattern 28[56%] patients. There was no statistical significant association between autonomic function pattern and age group of patients [p=0.536]. Also no statistical significant association were observed between autonomic dysfunction; and age, sex, disease duration, disease activity [SLEDAI],autonomic nervous system symptoms or drugs used [chloroquine, prednisolon, azathioprine] [p=0.434, p=0.213, p=0.405, p=0.450, p=0.069, p=0.935, p=0.204, p=0.443 respectively]. The incidence of autonomic dysfunction in Iraqi SLE patients using non-invasive tests is high [86%] and the most common pattern was the mixed pattern [56%]. Also there was no statistical significant association observed between autonomic dysfunction and age, sex, duration, SLE disease activity index [SLEDAI], drugs used, and autonomic nervous system symptoms