[Blood pressure and type 2 diabetes mellitus: impact of the insulin therapy]

The incidence of arterial hypertension is by 2-3 times with diabetics than with non-diabetics. Ethiopathogenesis of arterial hypertension in type 2 diabetes is multifactorial insulin-resistance, obesity, hyperlipoproteinemia, age, smoking and probably method of treatment [insulin therapy]. The aim of this retrospective study is to evaluate, over 5 years period, the level of blood pressure and the frequency's progression of arterial hypertension in 35 type 2 diabetes patients treated with insulin. Comparison of 35 type 2 diabetes patients treated with insulin to 35 controls treated with oral hypoglycemic agents. No significant differences were found over 5 years period in mean systolic blood pressure, mean diastolic blood pressure and frequency of arterial hypertension. However, frequency of arterial hypertension was correlated with mean dose of insulin. Our study confirms the long-term results found in the literature reading effects of insulin therapy on blood pressure in diabetic patients

[Food intake and high density lipoprotein cholesterol levels changes during ramadan fasting in healthy young subjects]

During the holy month of Ramadan, it is obligatory for all adult healthy Muslims to abstain from food, drink and smo-king each day from dawn to sunset. The aims of our study were to evaluate the effects of Ramadan fasting on plasma lipids, lipoproteins and the change of food consumption in healthy subjects. Thirty young healthy and normal weighted adults [9 males and 21 females] were evaluated during three periods: 3 weeks before Ramadan [TO]: the 4th week of Ramadan [T1] and 3 weeks after the end of Ramadan [T2]. Main Clinical and biological parameters investigated were: body weight. blood glucose, plasma triglycerides [TG], plas-ma total cholesterol [TC], high density lipoprotein cholesterol [HDL-c] and. low density lipoprotein cholesterol [LDL-c] Body weight, and blood glucose were unchanged. There was a significant increase of the mean daily caloric intake, the lipids intake particularly mono-unsaturated and poly-unsatu-rated fatty acids [p < 0,001] and cholesterol intake [p<0.001] during Ramadan with a decrease of the meal frequency. There was also a significant increase of plasma total cholesterol and HDL-cholesterol. The most striking finding was a significant increase in the HDL-Cholesterol during Ramadan +20% [p<0,02]. This increase was lost after Ramadan. Fasting Ramadan affects beneficially serum lipoprotein metabolism in young adult healthy subjects with an increase of HDL-cho-lesterol