Role and Research Progress of Phosphodiesterase Inhibitor in Gastrointestinal Tract / 胃肠病学

Phosphodiesterases (PDE) are a group of enzymes that can hydrolyze cyclic nucleotides. It is composed of 11 gene related isozyme families (PDE1-PDE11). Due to the diversity of isozymes, PDE distribute in different cells and sub-cells, regulate different intracellular signals and become an important target in intracellular signal pathway. Studies have shown that PDE inhibitor plays an important role in the regulation of gastrointestinal motility and related gastrointestinal diseases. This article reviewed the role and research progress of PDE inhibitor in gastrointestinal tract.