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Background and purpose:When the patients with nasopharyngeal carcinoma (NPC) receive radiotherapy, their thyroids are inevitably involved. As a result, thyroid damage occurs. This study aimed to explore the effects of intensity modulated radiation therapy (IMRT) on dynamics of thyroid blood flow in patients with NPC.Methods:A total number of 68 patients with NPC were enrolled in the study who received primary treatment of radical radiation and chemotherapy from Jul. 2012 to Oct. 2013. And the TMN stage was fromⅡ toⅣc according to UICC 2010. The treatment method consisted of 2 cycles of TPF induction treatment, concurrent radiation therapy (IMRT) with 2 cycles of DDP and 2 cycles of adjuvant therapy sequentially. Before radiotherapy, at the end of radiotherapy, 3 and 6 months after radiotherapy, serum free triiodothyronine (FT3), free thyroxin (FT4) and thyroid-stimulating hormone (TSH) concentrations of all cases were detected by electrochemiluminescence. The highest systolic velocity, mean velocity, minimum diastolic velocity, resistance index, and the value of all thyroid diameter lines were measured by type-B ultrasound.Results:All the patients were followed up for 6 months. Hypothyroidism: the incidence of immediate clinical hypothyroidism after radiotherapy was 5.9%; 3 months later, the incidence was 13.2%; and 6 months later, the incidence was 26.5%. The difference in volume change between before radiotherapy and at the end of radiotherapy had no statistical signiifcance (P>0.05). The difference in volume change between 3 and 6 months after radiotherapy had statistical signiifcance (P0.05).Conclusion:The incidence of hypothyroidism may increase with time after radiotherapy. The volume may decrease with the increased dose of radiotherapy and the follow-up time. The patients with NPC after radiotherapy should be tested for thyroid lesions routinely. The thyroid dose-volume parameter V40 may be a predictor for acute radioactive thyroid lesions. The study did not reveal temporarily that hypothyroidism was associated with thyroid ultrasound blood lfow velocity.
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OBJECTIVE: To evaluate the efficacy and toxicity of the sequential chemoradiotherapy of GP(GEM+DDP) versus concurrent chemoradiotherapy for localized Non-small cell lung cancer(NSCLC).METHODS: 64 patients with stage Ⅲa and Ⅲb NSCLC were divided into two groups: Sequential group were treated with gemcitabine(1 250 mg?m-2,on d1 and d8),cisplatin(30 mg?m-2 on d1～d3) followed radiotherapy;synchronous group were treated with gemcitabine(1 000 mg?m-2,on d1 and d8),cisplatin(20 mg?m-2 on d1～d3) plus concurrent radiotherapy.RESULTS: There was no difference in short-term efficacy and toxicity between the two groups but significant difference was noted in long-term effect.CONCLUSION: There were no difference between GP sequential treatment and concurrent chemoradiotherapy for localized NSCLC in short-term effect and toxicity,but synchronous group was better than sequential group in long-term effect.