RESUMO
Objective To study the effect of omeprazole combined itopride in treatment of functional dyspepsia and the safety.Methods 246 patients with functional dyspepsia were randomly divided into three groups,each group of 82 cases.Group A was treated with omeprazole,20mg each time,twice every day.Group B was treated with itopride,50mg each time,three times every day.Group C was treated with omeprazole combined itopride.All groups were treated for four weeks.Improvement of symptoms,clinical curative effect and safety were observed.Results The effective rate of early enough and after dinner full bilge symptoms of group C were 95.1％ and 95.3％,which were significantly higher than 64.6％ and 63.6％ of group A.The effective rate of abdominal pain and epigastric voiding symptoms of group C were 93.1％ and 90.8％,which were significantly higher than 67.2％ and 65.1％ of group B.The total effective rate of group C was 91.5％,which was significantly higher than 69.5％ of group A and 73.2％ of group B.All differences were statistically significant (P ＜ 0.05).Conclusion Omeprazole combined itopride in treatment of functional dyspepsia has definite curative effect,which is safety and worth of clinical promotion and popularization.