RESUMO
Hepatitis C virus [HCV] infection rate is rising in the underdeveloped world and genotype 3 is the 2nd most common subtype to involve. Sofosbuvir has shown good results in the recent times
Objective: To determine the efficacy of sofosbuvir for the treatment of hepatitis c genotype 3
Study Design: This was a descriptive case series study
Place of Study: Medical wards of Sheikh Zayed Hospital, Lahore
Period: From January 2016 to July 2016
Methodology: The cases of HCV infection of genotype 3 assessed by PCR were included. These cases then were treated with oral sofosbuvir in a dose of 400 mg daily along with RBV with age appropriate doses. The efficacy was labelled as yes when there was negative result on PCR done at completion of 3 months. Results: In the present study there were total 200 patients that had HCV PCR positive for genotype III, out of which 112 [56%] were males and 88 [44%] were females with mean age of 46.21 +/- 4.27 years. Efficacy of sofosbuvir was seen in 184 [92%] of the patients. This efficacy was better in those that had age 50 or less where it was seen in 118 [94.4%] of cases as compared to 66 [88%] with age more than this [p=0.07]. The duration of HCV less than 1 year revealed success rate of 96.67% as compared to 90% with p value of 0.08
Conclusion: Sofosbuvir has shown a very high efficacy rate in cases with HCV infection due to genotype 3 and results were near significantly better in those that had age less than 50 years and infection for less than 1 year
RESUMO
Abstract: Extracts from green and black cardamom have been used to evaluate their antioxidant potential for sunflower oil samples for a period of 45 days. Synthetic antioxidants BHA/ BHT were also used parallel over a period of 45 days for comparison. Antioxidant potential of natural and synthetic antioxidants were evaluated by measuring free fatty acids [FFA], peroxide value [PV] and iodine value [IV] values by ambient storage of sunflower oil. The results showed that green cardamom extracts were more effective compared to black cardamom extracts. However compared to BHA and BHT [200ppm], these were found to be effective at higher concentrations