To determine the effects of copper, zinc and magnesium in patients with pre-eclampsia

Objectives: Pre-eclampsia is hypertensive and multi-system related disorder of pregnancy. It has frequently labeled as "disease of theories". 5- 10% of pregnancies complicated due to pre-eclampsia and it is most common health problem worldwide. This study intended to estimates the copper, zinc and magnesium levels in patients with pre-eclampsia

Method: Total eighty subjects were included in the present study, from which 40 voluntaries were normotensive healthy pregnant women [controls], 40 were pre-eclamptic patients [cases]. The subjects were recruited having symptoms of interest after taking obstetric history, anthropometric and clinical data. After taking informed consent, blood sample collected and stored for biochemical analysis. The serum zinc, copper and magnesium levels were analyzed by Atomic Absorption Spectrophotometer. The study was conducted in biochemistry department during period of eight months from October 2015 to June 2016

Results:Total eighty subjects were included in present study. The trace elements decreased and shows significant difference between control healthy pregnant and pre-eclamptic women [p<0.05]. The mean difference of copper [0.15+/-0.07], zinc [2.94+/-0.45] and Mg[++] [0.15+/-0.09] mg/dl for the cases group and for control group copper was [0.20+/-0.03], zinc [5.11+/-0.21] and Mg[++] [2.17+/-0.21] mg/dl respectively

Conclusion: Trace elements are essential for the healthy pregnancy, suppressed concentration of serum Zinc, Copper and Magnesium may put forward the possible involvement in the pathology of pre-eclampsia. The aim of this study was to protects the mothers as well as her coming newborn from such life threating disease

To determine the role of co-enzyme Q10 and trace elements in patient with pre-eclampsia - a cross sectional study in Hyderabad

Objective: The pre-eclampsia is most common hypertensive and life threatening disorder during pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10 and trace elements has been proposed as novel factors concerned in development of pre-eclampsia

Study Design: Cross sectional, comparative study

Setting: Study was conducted in Biochemistry department Liaquat University of Medical and Health Sciences Jamshoro and patients were recruited from department of Obstetrics and Gynecology Liaquat University Hospital Jamshoro / Hyderabad Duration: 1[st] February 2015 to 30[th] October 2015

Methods: Total 210 volunteers were recruited, from which 50 volunteers were normotensive healthy pregnant women as a control and 160 were pre-eclamptic patients as cases. The subjects were recruited based on sign and symptoms, taking obstetric history, anthropometric, clinical data and collecting blood sample from volunteers. The CoQ10 was evaluated on HPLC while zinc, copper and magnesium on Atomic Absorption Spectrophotometer

Results: The plasma Co-Enzyme Q10 level were found decreased in pre-eclamptic patients [mean +/-S.D] [0.22+/-0.09]micro g/dl as compared with control group[1.08+/-0.37] micro g/dl with significant difference of p<0.05. Serum zinc, copper and magnesium levels in pre-eclampsia were decreased significanlty, it was noted as [2.94+/-0.44], Cu[++] [0.19+/-0.09] and Mg[++][1.16 +/- 0.08]mg/dl as compared with normotensive women [5.09+/-0.29], [0.36+/- 0.03] and [2.15+/- 0.09] mg/dl with significant difference of p<0.05 respectively

Conclusion: The observation showed that the CoQ10 and trace elements are essential for the healthy pregnancy, declined concentration of CoQ10 and essential trace elements may put forward the possible involvement in the pathology of pre-eclampsia

Healing of cornea following an electric burn

Electrical injuries have become a significant health problem in developing countries because of increase in access to electricity in the last few decades and lack of adequate safety measures. Electrical injuries of eyes are relatively uncommon. A case report of a rapid and complete corneal healing accompanied by satisfactory visual recovery after an electric burn event in a 20-year-old male is reported. The patient had accidental exposure to high voltage live wire while he was repairing it, resulting in severe ocular and superficial body burn. He was not wearing any protective equipment at the time of injury. On examination, the best-corrected visual acuity was counting fingers in the left eye with severe corneal epithelial loss and diffuse corneal oedema. The patient was treated medically, with a rapid corneal healing and resolution of oedema over the next few days. Visual acuity in the worse eye [left] improved to 20/25 from counting fingers

Primary chiasmal sarcoid granuloma masquerading as glioma of the optic chiasm

A 37-year-old woman presented with a 6 months history of headaches and memory impairment. Examination showed no neurological deficit with normal vision. MRI scans showed an enlarged optic chiasm. There was no dural or leptomeningeal enhancement or hydrocephalus. Open biopsy of the suprasellar mass showed non-caseating chronic granulomatous inflammation compatible with sarcoidosis. Systemic features of sarcoid were absent. Patient showed marked improvement on steroid therapy