RESUMO
Aim: The aim of this study was to design multi-walled carbon nanotubes [MWCNTs] loaded with paclitaxel [PTX] anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer
Background: Carbon nanotubes [CNTs] represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading
Patients and Methods: In this study, multi-walled carbon nanotubes [MWCNTs] pre-functionalized covalently with a paclitaxel [PTX] as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope [SEM], particle size analyzer and cellular analyses
Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line
Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport
RESUMO
Evidence is emerging for the association of polymorphisms in PRODH gene and increased risk of schizophrenia. In this project, peripheral blood sampling was obtained from 175 schizophrenia patients that their diseases were confirmed by psychiatrists. 185 healthy individuals were considered as control group. The related tests were administered on the basis of PCR-RFLP. In the continuation, statistical analysis was made on the basis of obtained genotypes from two groups of healthy and patient groups using SPSS16.0 software. The administration of this project aims at investigating the hypothesis that proline dehydrogenase gene, as one of the most important genes involved in schizophrenia incidence which is proved in various populations [outside Iran], may also be involved in incidence of schizophrenia in Iran. This study has analyzed one single nucleotide polymorphism in the PRODH gene, including 757C/T in the incidence of this disease in the given statistical population. According to our results, SNP 757 C/T may be effective in incidence of the disease since P value was < 0.01. Ultimately, our results suggest that outbreak of mutation in PRODH gene in our population can be one of causes of increasing risk of Schizophrenia in this population