randomized clinical trial of insulin Glargine and Aspart, compared to NPH and regular insulin in children with type 1 diabetes mellitus

Objective: Appropriate treatment of patients with Type 1 diabetes mellitus [T1DM] is necessary to avoid further complications. This study was performed to compare the efficacy of insulin Glargine and Aspart with NPH insulin and regular insulin regimen in a group of children with T1DM

Methods: Forty patients with T1DM were enrolled in this study. During run-in, all subjects were treated with conventional therapy consisting of twice-daily NPH and thrice-daily regular. Following randomization, 20 subjects received Glargine and Aspart and 20 subjects received NPH and Regular insulin

Findings: Mean HbA1c was 8.8% and 8.6% at first and 8.4% and 8.2% at the end of study for subjects randomized initially to Glargine and Aspart and for those randomized to NPH and Regular, respectively [P>0.05]. Mean fasting blood glucose [FBS] of the subjects randomized initially to Glargine and Aspart was 217+/-101 mg/dL, with no significant difference to 196+/-75 mg/dL for those randomized to NPH and Regular [P=0.48]. This was also true at the end of the study. The difference in total cholesterol and triglyceride between the two groups in the beginning of study and at the end did not show any significance

Conclusion: The current study showed no significant difference in glycemic control [Glycated hemoglobin [HbA1c] and FBS] and lipid profile [total cholesterol and triglyceride] between two regimes

value of simultaneous electrocardiography recording in the EEG laboratory

The aim of the current study was to assess the value of simultaneous EKG with EEG to diagnose cardiac disorders in patients with seizure- like attacks and to investigate the extent of misdiagnosis of epilepsy. 210 patients presenting with transient loss of consciousness [TLoC] and paroxysmal events suspicious to seizure were studied. All patients had undergone EEG simultaneous with an EKG. Besides reporting the EEG, a cardiologist analyzed the EKG in an attempt to recognize abnormal EKG as a potential cause of TLoC. Moreover, in all patients it was ascertained if any cardiac disorders in patients and their first degree relatives had been diagnosed. Sixteen out of two hundred ten [7.6%] patients had abnormal EKG which was significantly potential cause of symptom of whom 6 patients were found to have bradycardia and 10 patients had dysrhythmias. Moreover, in patients with previous cardiovascular disorder, 30.4% had abnormal EKG where as in patients without cardiac disease only 4.8% had EKG abnormalities. Besides in patients with positive family history for cardiac disease 20.3% had abnormal EKG while in patients without family history of cardiac disease, abnormal EKG was revealed in only 2.05% patients. Simultaneous EKG with EEG is valuable in declining rate of misdiagnosis of epilepsy. Besides, EKG abnormalities in these patients have a significant association with any previous cardiovascular disorders in the patients and in their first degree relatives

Association of vitamin D receptor with longevity and healthy aging

Longevity is a multifaceted trait in which variety of genes and environmental factors are involved. Newly, the role of vitamin D has been revived regarding its potential advantage on delaying the aging process. Vitamin D exerts its effect through vitamin D receptor [VDR]. VDR-FokI is the only polymorphism which alters the VDR length. We examined the frequency of FokI genotypes in old age population as compared to young adults to determine the discerning genotype of FokI polymorphism leading to longer living. In addition, to highlight the position of FokI polymorphism in quality of life; a cognitive function assessment was performed. 728 participants participated in this study of which 166 individuals were elderly residents of Kahrizak Charity Foundation. The rest were participants of Iranian Multicenter Osteoporosis Study [IMOS]. Genomic DNA was extracted from peripheral blood and VDR genotype was detected by the polymerase chain reaction. The participants in the elderly group underwent a cognitive function assessment. Cognitive function was measured with the mini mental state examination [MMSE]. Data were analyzed by SPSS 16.5. The prevalence of ff genotype showed 48% decrease in elderly population as compared to young adults [P=0.06]. In addition, F allele was over-represented in the elderly group as compared to controls [P=0.05]. Also, "FF" participants of elderly group had higher MMSE as compared to "ff" genotype [18.16Vs17.12]. Our data suggest that single nucleotide polymorphisms [SNPs] in FokI may be possibly involved in longevity and cognitive function