RESUMO
Microbiological transformation of diclofenac has been investigated using nineteen microbial species. The study showed that most organisms metabolized diclofenac sodium to different extents, to yield three metabolites that were identified by 2D NMR and MS analyses. The major metabolite was found to be 4hydroxydiclofenac while the other two were 5-hydroxydiclofenac and 4hydroxydiclofenac lactam. The three metabolites were also obtained as mammalian metabolites of diclofenac sodium, lending further support to the concept of microbial models of mammalian drug metabolism
Assuntos
Diclofenaco , Fenilacetatos , Transformação BacterianaRESUMO
The aerial of Maesa lanceolata yieded two new benzoquinones: 2-hydroxy-5- methoxy- 3- pentadecyl-1,4- benzoquinone [2] and 3- [[z]-10-pentadecenyl]-2.5-dihydroxy-6- methyl-1,4 benzoquinone [3]. Their structural assignments were largely based on 1D and2D NMR spectroscopic data and chemical derivatization. both compounds were found to be structurally related to the host defense stimulant maesanin [1]