Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma

Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized latanoprost, n = 60; dorzolamide/timolol, n = 60 to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure IOP after one, 3, and 6 months of treatment was compared with baseline in the 2 groups A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean standard error of mean [SE] IOP reductions at months one was 7.2 0.4, at month 3 was 7.3 0.4, and at month 6 was 7.1 0.3 mm Hg for the latanoprost group and 7.5 0.3, 7.8 0.3, and 7.4 0.3 mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective .The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline

Comparison of ultrasound and optic biometry with respect to eye refractive errors after phacoemulsification

Phacoemulsification is one of the best surgical treatments for the cataract. Secondary to the technical advances in estimating the intraocular lens [IOL] power, the refractive errors, one of the most important surgical complications after surgery, is now reduced. Currently, two methods of biometry are used to calculate the IOL power, ultrasound biometry and optical biometry. Both methods have their own advantages and it is controversial to use which of them before surgery. We would like to know if there is any difference between these two biometry methods to reduce refractive errors after cataract surgery. Present research was a cohort study on the patients undergone phacoemulsification due to cataract in Feiz and Farabi academic hospitals and Aban ophthalmology clinic. We compared eye refractions after cataract surgery in two groups of patients. Ultrasound biometry was done for the first group and the optical biometry for the second one. Mean absolute refractive error [MAE] was compared in the two groups by t test. Eye refractions of 132 patients were studied; 76 patients in group one and 56 patients in group two. The MAE measured 0.67 +/- 0.70 diopters for the first group and 0.79 +/- 0.76 diopters for the second one and the difference was not significant [P = 0.342]. According to our results the refractive errors after phacoemulsification was the same for both ultrasound and optical biometry methods. The claim of optical biometry, however, to gain a higher precision and thus a significantly better prediction of individual postoperative refraction after cataract surgery is not yet fulfilled. To determine which method is definitely better, more studies are required

Results of photorefractive keratectomy with mitomycin C for high myopia after 4 years

This study assessed the long-term results of photorefractive keratectomy [PRK] with mitomycin C in high myopia [>/= 7 diopter]. In this retrospective study, visual acuity, refractive error, pachymetry, topography, contrast sensitivity, corneal haze safety, predictability and complications [with emphasis on ectasia] of 37 high myopic patients [72 eyes] who had PRK surgery with mitomycin C in the last 10 to 40 months were assessed. The exclusion criteria included previous ocular surgery other than LASIK, current ocular disease and any systemic illness. The mean follow up period was 27.2 +/- 7.9 months. The spherical equivalent error was significantly reduced, from a mean of-9.10 +/- 2.12 diopters [D] [range of-7 to -18.25 D] before PRK to a mean of-1.81 +/- 1.57 D [range of-8.5 to 0 D] after [P = 0.001]. Postoperatively, 34.72% of eyes were within +/- 0.5 D of attempted correction and 58.33% within +/- 1 D and 84.72% within +/- 2 D. 80.5% of eyes had a vision of 20/40 or better. Best corrected visual acuity [BCVA] was unchanged or improved in 93.05%. The safety index was 0.96 [the ratio of mean postoperative BCVA [0.84] to mean preoperative BCVA [0.87]] and efficacy index was 0.8 [the ratio of mean postoperative unconnected visual acuity [0.7] to mean preoperative BCVA [0.87]]. Corneal haze formation was seen in 5 patients [6.9%] with grade +1. The minimum stromal residual bed was 400 micro m. No eyes had progressive corneal ectasias at the time of post-op control. The topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK. Predictability of refractive results, however, was poor