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1.
Archives of Iranian Medicine. 2012; 15 (6): 342-345
em Inglês | IMEMR | ID: emr-131263

RESUMO

Several studies have shown the prevalence of celiac disease [CD] to be around 1% in Iran, which is similar to the worldwide prevalence. There is scant information on occult CD in apparently healthy school age children. This study, as the first such study in Iran, aims to determine the prevalence of occult CD in healthy Iranian school age children. In this cross-sectional study, we screened healthy school age children for CD by serum IgA and IgA anti-tissue transglutaminase antibody [tTG] levels. Measurement of these antibodies was by enzyme linked immunosorbent assay. A recheck of positive tTG tests was performed and patients who tested positive underwent endoscopic duodenal biopsies. The biopsy samples were scored according to the Marsh classification by an experienced pathologist. A total of 634 children [314 males, 320 females; mean age: 12.8 years] were included in the study. All children and/or their parents completed a questionnaire and children underwent an initial physical examination to determine study eligibility. Positive serum tTG was noted in 3 [0.5%; 2 females] out of 634 patients. Duodenal biopsies were consistent with CD in these 3 subjects. The mean age of patients with CD was 14.3 years [range: 12-17 years]. The female to male ratio was 2:1. These cases had no signs and symptoms, but a gluten-free diet was recommended according to pathologic changes in their small bowels and results of the tTG test. The prevalence of occult CD in these children is 0.5%, which is half of the prevalence of CD in Iranian adults. The anti-tTG concentration at initial serological CD screening is highly informative in determining occult cases of CD. The question is whether all non-symptomatic cases should be treated with a gluten-free diet or not


Assuntos
Humanos , Masculino , Feminino , Prevalência , Instituições Acadêmicas , Criança , Estudos Transversais , Imunoglobulina A , Ensaio de Imunoadsorção Enzimática , Inquéritos e Questionários , Endoscopia Gastrointestinal , Endoscopia do Sistema Digestório , Duodeno/patologia
2.
Govaresh. 2005; 10 (4): 241-245
em Inglês | IMEMR | ID: emr-70708

RESUMO

Generalized lipodystrophy is a rare disorder in children characterized by absence of subcutaneous adipose tissue. We evaluated 10 patients with generalized lipodystrophy by skin and liver biopsy. Eight patients with steatohepatitis and cirrhosis were treated with Ursobile [uorsodeoxycholic acid] and vitamin E. In follow-up, serum triglyceride level was decreased


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Pele/patologia , Fígado/patologia , Ácido Ursodesoxicólico , Vitamina E , Estudos Retrospectivos , Lactente
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