[Ambulatory blood pressure measurement control in hypertensive treated diabetic patients]

Good blood pressure control is one of the recommended targets in diabetic patient's management.To evaluate blood pressure [BP] control in hypertensive treated diabetic patients using ambulatory blood pressure measurement [ABPM]. Two hundred and six hypertensive treated diabetic patients were enrolled in this study [83 men and 123 women]. Mean age were 60.3 +/- 9.6 years-old with mean diabetic duration of 9.1 +/- 8.2 years. All of them underwent 24 hours ABPM. Intervals between measurements were 20 minutes at diurnal period and 30 minutes at nocturnal period. 28 patients [13.6%] only were at recommended target levels of blood pressure control [mean diurnal BP < 130/80 mmHg and nocturnal BP < 115/65 mmHg] and 137 patients were at the most bed control levels [mean diurnal BP ? 140/90 mmHg or nocturnal BP ? 125/75 mmHg]. Bed controlled patients had mildly higher waist circumference [p=0.08]. Poor BP control was associated with non dipper character [p<0.001], diabetic nephropathy [p<0.01] and diabetic retinopathy [p<0.01]. Our hypertensive treated diabetic patients were far from good blood pressure control. ABPM showed that the loss of nocturnal blood pressure fall was the most associated abnormality with poor BP control. Diabetic microangiopathy were more frequent in poor controlled patients

[Cardiovascular risk factors in adults with primary hypothyroidism]

The purpose of this study is to evaluate vascular risk factors in adults with primary hypothyroidism. This retrospective study included 80 adult [age >/= 30 years] patients [60 women and 20 men], with primary hypothyroidism. The mean age at diagnosis was 52.8 +/- 12.1 years, the mean BMI was 30.8 +/- 5.8 kg/m[2] and 46.3% of the patients were obese while 28.8% had overweight. Mean total cholesterol was 2. 74 +/- 0.83 g/l and 83.7% of patients had hyper-cholesterolemia. LDL cholesterol level was above 1.6 g/l in 65.2% of cases. Mean triglycerides was 2.01 +/- 1.14 g/l and 41.2% of patients had hypertriglyceridemia. 22.5% of patients had hypertension and 8.8% were diabetic. Coronary heart disease was diagnosed in 11 patients [13.8%] and was significantly associated with age and hypertension. These results underline the expected high frequency of overweight and dyslipidemia in adults with hypothyroidism, despite a low frequency of diabetes and hypertension

Blood glucose control in the first year in diabetes type 1

The purpose of this study is to analyze the blood glucose control in the first year after the diagnosis of type 1 diabetes. This retrospective study included the data on 52 patients [age< 30 years] with type 1 diabetes who were admitted at the time of diagnosis, seen afterwards in our outpatient department and who had at least one HbAlc determination during follow-up. Our evaluation included 29 female and 23 male diabetic patients, with a mean age of 21.3 +/- 4.5 years and mean initial BMI of 20.0 +/- 4.6 kg/m2 at the time of diagnosis. In more than 75% of the cases, during the year following diagnosis, HbAlc was determined one to two times and the mean level was 8.41 +/- 2.76%. HbAlc level was less than 7% in 38.5% of cases, and this group, when compared to the other group [HbAlc >/= 7%] was characterized by a higher baseline BMI [21.4 +/- 3.4 vs 19.2 +/- 3.1 kg/m 2, p<0.02] and less insulin requirements. These results show that an optimal blood glucose control in type 1 diabetes is difficult to obtain even in the first year after the diagnosis

[Glycemic control in patients with type 2 diabetes]

Long term blood glucose control is still difficult to obtain in type 2 diabetic patients. To evaluate quality of control, we analyzed data from 300 patients who attended our outpatient department in 2002 and performed at least one glycated hemoglobin measure. Mean age was 59.9 +/- 10.2 years; 58.7% were women and known duration of diabetes was 11.0 +/- 74; years. The glycated hemoglobin level was less than 7% in 21.3% of patients; those having lower duration of the disease, being more frequently treated with oral drugs, having a better control of other cardio vascular risk factors and having more frequent screening for complications. These results confirm the difficulty in obtaining optimal glucose control in patients with type 2 diabetes and the need for intensive anti-diabetic treatment