RESUMO
Objective: Fentanyl is frequently used during anesthesia induction. The use of fentanyl can cause cough through different mechanisms. Here, we aimed to investigate effects of pheniramine maleate [PM], an antihistaminic agent, and compare it with lidocaine on fentanyl induced cough
Methods: This is a randomized double-blind prospective clinical study of ASA I-II, 120 patients scheduled for elective abdominal surgery. Patients were administered drugs intravenously and randomly allocated into three groups: Group C [2 ml 0.9 % normal saline], Group L [1mg/kg lidocaine], and Group F [PM 45.5 mg]. 90 seconds after administration, 2 micro/kg fentanyl was applied in three seconds to all patients. Severity of cough [mild: 1-2, moderate: 3-5, severe> 5], time of the cough and vital parameters were recorded 90 seconds after fentanyl injection
Results: Eight patients [25%] in Group C had fentanyl induced cough whereas three patients [7.5%] in Group L and one patient [2.5%] in Group F experienced this phenomenon. There was statistically significant difference between Group F and Group C [p<0.05]; however, differences between Group L and Group C or Group F and Group L were not statistically significant [p>0.05]
Conclusions: Pheniramine Maleate 45.5 mg is better that placebo and as effective as lidocaine to prevent fentanyl induced cough