Clinical, oro dental and cytogenetic studies in some cases of papillon-lefevre syndromes and prepubertal periodontitis

Prepubertal peripdontitis is a rapidly prognessive form of early onset periodontitis leading to destruction of the periodontal support of the primary and secondary dentition. The aim of this study is to determine the basics for genetic mapping of six Egyptian cases suffering from prepubertal periodontitis and its variants. After completion of clinical assessment, cytogenetic study was performed for all cases including chromosomal analysis and plain X-ray for their hands. The gentic study revealed arachnodactyly of their hands, However no radiographic deformity of their fingers was detected. The cytogenetic study for all patients did not show any abnormality. This study might have important implications on oral public health, and in diagnosis and treatment of periodontitis

Immunolocalization of vascular and non vascular expression of VCAM-1 in hyperplastic, dysplastic oral mucosal lesions and squamous cell carcinoma

38 oral biopsy specimens of hyperplastic surface epithelial lesions [8 cases], epithelial dysplastic lesions [12 cases] and squamous cell carcinoma [SCC] [18 cases] as well as six biopsies of normal oral mucosa were processed for immunohistochemical staining with anti VCAM-1 to identify vascular and non vascular expression of VCAM-1 in the hyperplastic and dysplastic oral lesions as well as oral SCC compared to normal oral mucosa and to examine if it has an active role in the pathogenesis of these lesions that could point the way to the developing of new therapeutic stratigies. The results of this study suggested that VCAM-1 expression has essentially a direct relation with the density and distribution of chronic inflammatory cell infiltration. VCAM-1 is not related to the different grades of epithelial dysplasia and tumor cell differentiation. It cann't be also used as an indicator of tumor angiogenesis