RESUMO
Objective To investigate the effect of azithromycin and cefiazidime on serum lactate dehydrogenase (LDH) in children with refractory mycoplasma pneumoniae pneumonia.Methods From January 2014 to January 2017,120 children with refractory mycoplasma pneumoniae pneumonia in Women and Infants Hospital of Zhengzhou were selected as research object,all the cases were equally divided into observation group and control group with 60 cases in each group according to the random draw envelope principle,the observation group was given azithromycin adjuvant treatment,the control group was given cephalosporin adjuvant therapy,two groups were treated for 14 d.Results The total effective rates of observation group and control group were 98.3％ and 86.7％,respectively,the total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant (P ＜ 0.05).The serum levels of LDH in observation group and control.group after treatment were (143.22±26.29) and (245.10 ± 30.91) U/L that were significantly lower than those before treatment of (445.20 ± 35.10) and (438.10 ± 56.11) U/L (P ＜ 0.05),and the serum level of LDH in observation group after treatment was significantly lower than that of the control group (P ＜ 0.05).The incidence of adverse reactions such as rash,gastrointestinal reaction,pain,fever and other adverse reactions in the observation group was 11.7％,which was 10.0％ in the control group.Comparison between the two groups had not significant difference (P ＜ 0.05).Conclusion Compared with cephalosporins,azithromycin in the treatment of refractory mycoplasma pneumoniae pneumonia in children can improve the therapeutic effect,and does not increase the incidence of adverse reactions,the mechanism may be related to the decrease of the content of serum LDH.
RESUMO
Objective To investigate the effect of azithromycin and cefiazidime on serum lactate dehydrogenase (LDH) in children with refractory mycoplasma pneumoniae pneumonia.Methods From January 2014 to January 2017,120 children with refractory mycoplasma pneumoniae pneumonia in Women and Infants Hospital of Zhengzhou were selected as research object,all the cases were equally divided into observation group and control group with 60 cases in each group according to the random draw envelope principle,the observation group was given azithromycin adjuvant treatment,the control group was given cephalosporin adjuvant therapy,two groups were treated for 14 d.Results The total effective rates of observation group and control group were 98.3％ and 86.7％,respectively,the total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant (P ＜ 0.05).The serum levels of LDH in observation group and control.group after treatment were (143.22±26.29) and (245.10 ± 30.91) U/L that were significantly lower than those before treatment of (445.20 ± 35.10) and (438.10 ± 56.11) U/L (P ＜ 0.05),and the serum level of LDH in observation group after treatment was significantly lower than that of the control group (P ＜ 0.05).The incidence of adverse reactions such as rash,gastrointestinal reaction,pain,fever and other adverse reactions in the observation group was 11.7％,which was 10.0％ in the control group.Comparison between the two groups had not significant difference (P ＜ 0.05).Conclusion Compared with cephalosporins,azithromycin in the treatment of refractory mycoplasma pneumoniae pneumonia in children can improve the therapeutic effect,and does not increase the incidence of adverse reactions,the mechanism may be related to the decrease of the content of serum LDH.
RESUMO
<p><b>OBJECTIVE</b>To summarize the experience of urethral reconstruction using circular fasciocutaneous flap for the treatment of complex anterior urethral strictures.</p><p><b>METHOD</b>The circular fasciocutaneous flap was harvested from the distal penile shaft or foreskin. Then the circular configuration was converted into longitudinal strip of skin which was rotated to ventral side to repair the exposured urethral strictures using the ventral onlay method. The surveillance protocol after urethroplasty was urination observation, regularly uroflowmetry and urethrography examination.</p><p><b>RESULTS</b>From Nov. 2006 to Oct. 2012, 15 cases were treated. The mean age was 45 years (20-76 years) and mean follow-up period was 18 months(3 months-3 years). Stricture was caused by chronic urethritis in 4 cases, long-term urethral catheterization in 3 cases, transurethral perfusion chem other aphy in 3 cases, transurethral prostatectomy in 3 cases and hypospadias after surgery in 2 patients. The mean stricture length was 7.0 cm (3.5-12.0 cm). The overall success rate was 80.0% (12/15). Recurrence stenosis was noted in 2 cases and diverticulum formation in 1 case.</p><p><b>CONCLUSIONS</b>The penile circular fasciocutaneous flap can be used for anterior urethral stricture in nearly any length. The flap has the characteristics of hairless, adequate mobile and length, well-vascularized pedicle and easy to harvest. The onlay reconstruction provides excellent cosmetic results, less trauma, higher success rate. Therefore it should be one of the preferred techniques for complex anterior urethral stricture repair.</p>