Progress of Research on Therapeutic Drug Monitoring in Treatment of Novel Biological Agents for Inflammatory Bowel Disease / 胃肠病学

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease, and its treatment includes traditional medicines and biological agents. Therapeutic drug monitoring is an important tool to optimize the treatment of biological agents. Therapeutic drug monitoring of tumor necrosis factor inhibitors has been used to guide the clinical decision ⁃ making. However, the value of therapeutic drug monitoring of novel biological agents (vedolizumab and ustekinumab) in IBD remains unclear. This article summarized the pharmacokinetics, drug concentration and treatment outcome, optimization of the novel biological agents in the treatment of IBD.

Effect of Ganoderma capsule on expressions of CD105 protein and miR-21 in cervical cancer tumor tissue associated with HPV infection / 中国生化药物杂志

Objective To investigate the effect of Ganoderma capsule on the expression of CD105 protein and miR-21 in cervical cancer tumor tissue associated with human papillomavirus ( HPV) infection.Methods 162 patients with HPV positive cervical cancer from the department of oncology in Cixi City Hospital of traditional Chinese Medicine were selected and divided into two groups, 81 cases in the control group were treated with neoadjuvant chemotherapy, 81 cases in the experiment group received Ganoderma capsule on the basis of the control group , the expression levels of CD105 protein, vascular endothelial growth factor (VEGF), miR-21 in tumor tissues, microvessel formation correlation indexes, peripheral blood T lymphocyte levels, and the clinical effect were compared after the treatment.Results The control rate in the control group(72.84%)was lower than the experiment group(86.41%) (P<0.05).Compared with the control group, the expression levels of CD105 protein, VEGF in tumor tissue were lower in the experiment group after treatment, serum levels of CD105 protein,transforming growth factor-β1 (TGF-β1), VEGF were lower after chemotherapy, the expression level of miR-21 was lower after treatment, peripheral blood CD4 +T lymphocytes and CD4 +/CD8 +ratio levels were higher, and the level of CD8 +T lymphocytes was lower after chemotherapy(P<0.05).Conclusion The Ganoderma capsule can significantly down regulate the expression of CD105 protein, VEGF and miR-21 in cervical cancer tumor tissue associated with HPV infection, inhibit the formation of micro blood vessels in tumor tissue, protect the immune function of patients, and improve the clinical curative effect.

Analysis of risk factors for hypertension among taxi drivers on different shifts / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To investigate the incidence and risk factors for hypertension among taxi drivers working different shifts.</p><p><b>METHODS</b>Using the cluster sampling method, 415 day-shift and 304 night-shift taxi drivers in Jinan, China were selected and investigated. The influencing factors for hypertension were analyzed.</p><p><b>RESULTS</b>The incidence of hypertension in all taxi drivers was 33.2%. The incidence of hypertension in night-shift drivers was significantly higher than that in day-shift drivers (37.8% vs 29.9%, P<0.05). According to multivariate analysis, the incidence of hypertension in day-shift drivers was closely related to body mass index (BMI), working years, working hours, sleep duration, rest days, diet quality, water intake, and smoking, while the incidence of hypertension in night-shift drivers was closely related to BMI, working years, working hours, part-time job, sleep duration, rest days, and drinking.</p><p><b>CONCLUSION</b>BMI, working years, and working hours are the common risk factors for hypertension in day-shift and night-shift drivers. Sleep duration and rest days are the common protective factors. The risk factors for hypertension in taxi drivers vary with different shifts.</p>