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Rev. Inst. Med. Trop. Säo Paulo ; 44(2): 67-70, Mar.-Apr. 2002. tab
Artigo em Inglês | LILACS | ID: lil-308008

RESUMO

As little is known about liver histology in the co-infection of hepatitis C virus (HCV) and hepatitis G virus (HGV), HGV RNA was investigated in 46 blood donors with hepatitis C, 22 of them with liver biopsy: co-infection HCV / HGV (n = 6) and HCV isolated infection (n = 16). Besides staging and grading of inflammation at portal, peri-portal and lobular areas (Brazilian Consensus), the fibrosis progression index was also calculated. All patients had no symptoms or signs of liver disease and prevalence of HGV / HCV co-infection was 15.2 percent. Most patients had mild liver disease and fibrosis progression index, calculated only in patients with known duration of infection, was 0.110 for co-infection and 0.130 for isolated HCV infection, characterizing these patients as "slow fibrosers". No statistical differences could be found between the groups, although a lesser degree of inflammation was always present in co-infection. In conclusion co-infection HCV / HGV does not induce a more aggressive liver disease, supporting the hypothesis that HGV is not pathogenic


Assuntos
Humanos , Hepatite Viral Humana , Fígado , RNA Viral , Doadores de Sangue , Progressão da Doença , Flaviviridae , Infecções por Flaviviridae , Hepatite C , Cirrose Hepática , Prevalência , Estatísticas não Paramétricas
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