Evaluation of Antimicrobial Photodynamic Therapy as an Adjuvant in Periodontal Treatment in Individual with Down Syndrome

Abstract Objective: To evaluate the effectiveness of Antimicrobial Photodynamic Therapy (aPDT), associated with scaling and root planing in the non-surgical periodontal treatment of individuals with Down Syndrome. Material and Methods: A controlled, randomized, split-mouth study was conducted. A total of 8 participants diagnosed with Down Syndrome aged 17-38 years of both sexes with clinical periodontitis were included in the study. Participants were treated at least three times: at the baseline, Plaque Index (PI), Bleeding on Probing (BOP), and Probing Pocket Depth (PPD) were obtained. After one week, conventional scaling and root planing were performed, and two quadrants were randomly selected for aPDT application. The reassessment was obtained one month after the aPDT application. The significance level was set at 5%. Analyses were performed considering a 95% confidence interval. Results: In the intergroup evaluation, no statistically significant differences were observed (p>0.05). In the intragroup evaluation, no statistically significant variations were observed in relation to the PI (p>0.05) and PPD (p>0.05); however, a statistically significant reduction in the BOP was observed between the test group (p=0.013) and control group (p=0.015). Conclusion: The use of aPDT as adjuvant therapy did not promote additional benefits in decreasing PI and PPD after 1 month of treatment. However, a significant reduction in the BOP was observed in the intragroup evaluation.

Brazilian Scientific Research about Acupuncture in Dentistry: Bibliometric Analysis of the Papers Presented at SBPqO Meetings / A Pesquisa Científica Brasileira Sobre Acupuntura na Odontologia: Análise Bibliométrica dos Trabalhos Apresentados nas Reuniões da SBPqO

The aim of this study was to investigate the Brazilian scientific production about acupuncture in dentistry, outlining the profile of the works about the subject presented at the Meetings of the Brazilian Society of Dental Research (SBPqO). It was a cross-sectional study, with a quantitative approach, based on secondary data. An analysis of all abstracts presented in the last ten SBPqO Meetings (2009-2018) published in the annals of the event was carried out. For the research the location of the term "acupuntura" or "acupuncture" among the abstracts was realized and the following information was collected: type of institution that carried out the research (public or private), Brazilian region where it was realized, area or specialty of dentistry and whether it involved humans or animals. Of the 26,514 dental research abstracts published in the annals, only 27 papers were experimental studies or systematic reviews about the subject. Of the total, 23 (85.2%) were developed in public institutions, 15 (55.6%) did not receive financial support 20 (74.1%) were carried out in humans and 13 (48.2%) were developed in the Southeast region. Regarding the dental specialty, the majority (70.4%) investigated acupuncture in "Temporomandibular Dysfunction and Orofacial Pain". Therefore, it can be concluded that few acupuncture studies in dentistry have been developed in the last ten years in Brazil, according to the papers presented at the SBPqO Meetings. Thus, it is suggested that research on the subject be carried out and widely disseminated between the academic and professional milieu. (AU)

O objetivo desse estudo foi investigar a produção científica brasileira sobre a acupuntura na odontologia, traçando o perfil dos trabalhos sobre a temática apresentados nas Reuniões da Sociedade Brasileira de Pesquisa Odontológica (SBPqO). Tratou-se de um estudo transversal, com abordagem quantitativa, a partir de dados secundários. Realizou-se uma análise de todos os resumos apresentados nas últimas dez Reuniões da SBPqO (2009-2018) publicados nos anais do evento. Para pesquisa procedeu-se a localização do termo "acupuntura" ou "acupuncture" entre os resumos e foram colhidas as seguintes informações: tipo de instituição que realizou a pesquisa (pública ou privada), região rasileira onde foi realizada, recebimento de auxílio financeiro, área ou especialidade da odontologia e se envolvia humanos ou animais. Dos 26.514 resumos de pesquisa odontológica publicados em anais, apenas 27 trabalhos tratavam de estudos experimentais ou revisões sistemáticas sobre a temática. Do total, 23 (85,2%) foram desenvolvidos em instituições públicas, 15 (55,6%) não receberam auxílio financeiro, 20 (74,1%) foram realizados em humanos e 13 (48,2%) desenvolvidos na região Sudeste do Brasil. Com relação a especialidade odontológica, a maioria (70,4%) pesquisou sobre a acupuntura na "Disfunção Temporomandibular e Dor Orofacial". Os achados do presente estudo indicam que poucas pesquisas abordando a acupuntura na odontologia foram desenvolvidas nos últimos dez anos no Brasil, de acordo com os trabalhos apresentados nas Reuniões da SBPqO. Diante disso, sugere-se que pesquisas sobre o tema sejam realizadas e amplamente divulgadas entre o meio acadêmico e profissionais. (AU)

Evaluation of the Adjuvant Effect of Antimicrobial Photodynamic Therapy in the Treatment of Periodontal Disease: Literature Review / Avaliação do Efeito Adjuvante da Terapia Fotodinâmica Antimicrobiana no Tratamento da Doença Periodontal: Revisão de Literatura

Antimicrobial Photodynamic Therapy (aPDT) is a promising approach with several clinical applications, including the treatment of periodontal diseases, by acting as an adjuvant to the conventional treatment of periodontal disease by allowing reduction of periodontopathogens, with no systemic side effects and minimal possibilities of bacterial resistance. Objective: To verify, through the scientific literature, the effectiveness of Antimicrobial Photodynamic Therapy associated with conventional periodontal treatment. Methodology: The literature review was conducted in the MEDLINE databases - PubMed, Scopus and Web of Science. The articles were selected through the analysis of titles and abstracts published in the period from 2007 to 2018. Selected articles were published in their entirety and with free or controlled access, of the type clinical trial on the subject, without restriction of languages. The terms used were: "Periodontal diseases"; "Chronic Periodontitis" and "Photochemotherapy." Results: 84 articles were found, and 20 clinical trials that met the inclusion criteria were analyzed. There were different clinical protocols for the association of aPDT with the conventional treatment of periodontal disease. a number of different clinical outcomes were found for each of the proposed clinical protocols. Conclusion: Considering the clinical trials investigated, conflicting results regarding the efficacy of aPTD as an adjuvant treatment of the conventional treatment of periodontal disease are observed. and lack of standardization of clinical parameters and protocols. (AU)

A terapia fotodinâmica antimicrobiana (aPDT) é uma abordagem promissora com várias aplicações clínicas, incluindo o tratamento das doenças periodontais, ao atuar como um adjuvante ao tratamento convencional da doença periodontal por permitir redução de periodontopatógenos, com ausência de efeitos sistêmicos colaterais e mínimas possibilidades de resistência bacteriana. O objetivo deste estudo é verificar, por meio da literatura científica, a eficácia da terapia fotodinâmica antimicrobiana associada ao tratamento periodontal convencional. A revisão de literatura foi conduzida nas bases de dados MEDLINE ­ PubMed, Scopus e Web of Science. Os artigos foram selecionados através da análise de títulos e de resumos publicados no período de 2007 a 2018. Foram selecionados artigos publicados na íntegra e com acesso livre e gratuito, ou controlado, do tipo ensaio clínico sobre o tema, sem restrição de idiomas. Os termos utilizados foram: Periodontal diseases; Chronic Periodontitis e Photochemotherapy. Foram encontrados 84 artigos, e 20 ensaios clínicos que atenderam os critérios de inclusão, foram analisados. Observou-se diferentes protocolos clínicos para a associação da aPDT com o tratamento convencional da doença periodontal. Também foram encontrados diferentes desfechos clínicos para cada um dos protocolos clínicos propostos. Conclusão: Considerando os ensaios clínicos pesquisados, observa-se resultados conflitantes frente à eficácia da aPDT como tratamento adjuvante do tratamento convencional da doença periodontal. Observa-se, ainda, uma produção literária escassa e a falta de uma padronização dos parâmetros e dos protocolos clínicos. (AU)

Fototerapia no tratamento da mucosite oral: uma revisão de literatura / Phototherapy in the treatment of oral mucositis: a literature review

Objetivo: O presente estudo tem por objetivo relatar as características da mucosite oral e o efeito da fototerapia no tratamento desta condição. Métodos: Realizou-se uma pesquisa bibliográfica nas bases de dados eletrônicas Web of Science, Scopus, PubMed e Scielo. A estratégia de busca foi baseada na pesquisa dos descritores "LLLT", "Low-Level Laser Therapy", "Light, phototherapy", "phototherapy", "Photobiomodulation Therapy" "Photobiostimulation Laser Irradiation", "Laser", "Mucositis" e "Oral Mucositis". Resultados:Após a análise dos artigos completos, 22 artigos foram considerados adequados para serem incluídos na revisão, sendo um publicado em 2012 (4,5%), um em 2013 (4,5%), dois em 2015 (9,1%), dois em 2016 (9,1%), quatro em 2017 (18,2%), nove em 2018 (40,9%) e três em 2019 (13,7%). Conclusão: Pode-se concluir que a laserterapia é eficaz na prevenção e tratamento da mucosite oral induzida por quimioradioterapia, reduzindo a dor e promovendo a cicatrização tecidual. (AU)

Aim: This study aims to report the characteristics of oral mucositis and the effect of phototherapy in the treatment of this condition. Methods: A bibliographic search was done in the electronic databases Web of Science, Scopus, PubMed, and Scielo. The search strategy was based on the research of the following descriptors: LLLT, Low-Level Laser Therapy, Light, phototherapy, phototherapy, Photobiomodulation Therapy, Photobiostimulation Laser Irradiation, Laser, Mucositis, and Oral Mucositis. Results:After reviewing the full articles, 22 articles were considered adequate to be included in the review, with one published in 2012 (4.5%), one in 2013 (4.5%), two in 2015 (9.1%), two in 2016 (9.1%), four in 2017 (18.2%), nine in 2018 (40.9%), and three in 2019 (13.7%). Conclusion: It can be concluded that laser therapy is effective in the prevention and treatment of oral mucositis induced by chemoradiotherapy, reducing pain and promoting tissue healing. (AU)