Efeito metafilático do zinco injetável sobre parâmetros metabólicos e oxidativos de ovelhas no pós-parto imediato / Metaphylactic effect of injectable zinc on metabolic and oxidative parameters of sheep in the immediate postpartum

The aim of this study was to evaluate a new source of injectable organic zinc (zinc edetate) on the energy and oxidative profile in sheep during the immediate postpartum period. Twenty-six Texel breed animals were previously identified and divided into two experimental groups: the treated group (TG; n= 13) that comprised the animals that received a subcutaneous (SC) injection of 100 mg of zinc edetate (2 mL) fifteen days before the parturition expected date and the control group (CG; n=13) that comprised the animals that received 2mL of physiological solution at the same date of TG. Blood samples were collected on the parturition day for the assessment of serum fructosamine, cholesterol and triglycerides, insulin-like growth factor type 1 (IGF-1), the oxidative stress index (OSi) and blood zinc concentration. In addition to these parameters, the measurement of zinc was made in food given to the animals. There was no difference in metabolic parameters and OSi between the experimental groups (P>0.05), as well as in blood zinc concentrations (P>0.05). The parenteral zinc edentate does not change the energy and oxidative profile of sheep in immediate postpartum.(AU)

Avaliação funcional e histológica da tireoide de ovinos suplementados com fluoreto de sódio por um período de 150 dias / Functional and histological evaluations of thyroid of sheep submitted to sodium fluoride administration

Avaliou-se o efeito da administração de fluoreto de sódio sobre a tireoide de 12 ovinos, distribuídos em dois grupos: o grupo controle (n=6) recebeu somente sal iodado (5g de NaCl/animal + 0,2ppm I/kg MS) e o grupo tratado (n=6), sal iodado (5g de NaCl/animal + 0,2ppm I/kg MS) adicionado de fluoreto de sódio (4,7mg F/kg de peso corporal), durante 150 dias. Amostras de sangue foram coletadas para análise sérica de I e F, triiodotironina (T3) e tetraiodotironina (T4) nos dias zero, 60, 90 e 150 de tratamento. Também se coletou urina, correspondente às 24 horas, para análise da excreção urinária de I e F. Após a eutanásia dos animais, a tireoide foi removida para posterior exame. Quanto ao I urinário, não foi observada diferença estatística entre os grupos controle e tratado e dentro de cada grupo, entre os tempos. As concentrações de T3 e T4 não diferiram entre os grupos e dentro de cada grupo nos diferentes tempos. Quanto à avaliação histopatológica da tireoide, não foram observadas alterações na integridade estrutural. Conclui-se que a administração crônica de fluoreto de sódio não interfere na função e na integridade histológica da glândula tireoide de ovinos com dieta não restritiva de iodo.

The effect of sodium fluoride administration on thyroid function and morphology in sheep was evaluated using 12 lambs. Animals were allotted in two groups: control that received 5g NaCl + 0.2ppm I/kg DM and treated which received the same treatment plus sodium fluoride (4.7mg F/kg BW), daily, for 150 days. Blood samples were collected for determination of F, I, T3, and T4. Urine production was collected for measurement of F and I. After euthanasia at 150 days of treatment, thyroid glands were removed for analysis. No differences were found between or within groups for urinary I. Also, no differences were found for T3 and T4 on serum I between groups or among time points. No histological alterations were found in the thyroids. In conclusion, chronic sodium fluoride treatment did not affect thyroid function and morphology in lambs.