Prostaglandin A1, inhibits replication of Classical Swine Fever Virus

Prostaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 µg/ml, which was nontoxic to the cell, PgA1 inhibits virus production in 99 per cent. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.