Antioxidant defense of pycnogenol against glycerol induced acute renal failure in mice

The present study aims to demonstrate the efficiency of pycnogenol as a protector in male mice against hazards effect in kidney functions induced by glycerol. Mice were received i.m. injection 50% glycerol [8ml/ kg b.wt] 30 minutes prior to glycerol administration, other group received orally pycnogenol [400mg/ kg b.wt] over a period of 12 hours. Lipid peroxidation products [MDA, PC], non-enzymatic and enzymatic antioxidant [GSH, CAT, SOD] were estimated, in addition serum protein, urea, createnine concentration as well as serum Na, K levels were determined. It seems that rhabdomyolysis effect caused by glycerol can be controlled to some extent by pycnogenol administration

Therapeutic effect of lycopene-rich tomato juice on cardiac disorder in rats fed on fried food in oxidized frying oil

Therapeutic effect of lycopene-rich tomato juice against evoked cardiac disorders in rats fed on fried potato in oxidized frying cotton seed oil [20% w/w] for 4-weeks was studied using lycopene at a daily dose of 1 mg/Kg body weight. Total lipids, total cholesterol, triglycerides, phospholipids, low-density lipoprotein cholesterol [LDL-c] and high-density lipoprotein cholesterol [HDL-c] were estimated in different animal groups. Lactic dehydrogenase [LDH], creatine kinase [CK], aspartate aminotransferase [AST] and alanine aminotransferase [ALT] as well as serum calcium, potassium and magnesium were determined. The obtained results revealed that, feeding on fried potato in deep oxidized frying oil induced a notable increase in lipid profils and LDL-c associated with a marked elevation in specific heart enzymes, LDL, CK, ALT and AST activities. These biochemical alterations ameliorated when lycopene was administered to rats fed fried potato in oxidized frying oil