[Evaluation of glucantime activity in cutaneous leishmaniasis lesions contaminated with secondary bacterial infection compared with non infected lesions]

Background: glucantime is regarded as the first line in the treatment of cutaneous leishmaniasis, but failure to treatment is a problem in many cases. óEvaluation of glucantime activity in the cutaneous leishmaniasis complicated with secondary bacterial infection compared with uncomplicated lesions

Materials and Methods: this experimental clinical trial Patients enrolled in the study had cutaneous leishmaniasis. The lesions were scraped with sterile swap and cultured into the blood agar medium. All the patients were treated with systemic glucantime for 3 weeks and followed for 2months. Response to treatment was defined as loss of infiltration, re epithelization and negative smear, and unresponsiveness defined as unchanging the size of the lesions without re epithelization and positive smear at the end of the study. Regarding to results of cultures, the lesions were divided into two groups with positive and negative cultures and glucantime activity was compared between two groups

Results: out of 161 patients enrolled in the study, 123 [76.4%] were Negative and 38 patients [23.6%] were Positive for secondary bacterial infection. In groups with negative bacterial culture response to treatment was 65 % [80 Patients] and in the other group was 31.6% [12 patients] [X2= 13.77, P<0.01]

Conclusion: activity of glucantime decreased in cutaneous leishmaniasis lesions with secondary bacterial infection

Percutaneous laser photocoagulation in the treatment of benign solitary thyroid nodules

Thyroid nodules are common and surgery is the usual treatment. One of the common complications after thyroid surgery is keloid formation in front of the neck which is an important cosmetic problem. Nodular goiter is a common disorder of thyroid and its common treatment is surgery. Considering the fact that with clinical evaluation and FNA, the risk of malignancy in these cases is low a non aggressive approach to this complication is necessary. This study aims to evaluate of the effectiveness of percutaneous laser photocoagulation [PLP] in reducing the volume of benign thyroid nodules. In this case-controlled clinical trial, 39 female euthyroid patients with solitary solid benign thyroid nodules were enrolled 18 patients were treated with ultrasound guided percutaneous laser photocoagulation, and 21 patients were included in the control group. PLP was performed by diode surgical laser with 1-3 watt output for 123-1019 seconds. All patients were followed up for 3 months. After PLP, mean nodule volume decreased from a baseline value of 26.3 +/- 23 mL to 15.1 +/- 13 at 3 months. Mean nodule volume reduction in comparison with baseline was 42.72%. Compressive symptoms showed relative decrease. No serious complication was seen, nor was any keloid or scar observed in the front of the neck. PLP can be a minimally invasive effective alternative treatment for symptomatic benign solitary solid thyroid nodules in patients not suitable for surgery

[Therapeutic effects of paromomycin sulfate in combination with grntamicine sulfate films on cutaneous leishmaniosis in Balb/c mice]

Leishmaniosis is a complex disease, with a wide spectrum of clinical manifestation affects over 12 million people globally. Cutaneous leishmaniosis is still an important public health problem in many parts of the world, especially the Middle East. In spite of various forms of local treatment none is generally suitable for all forms of the disease in all. In this reseal-cli, therapeutic effects of paromomycin sulfate in combination with gentamicine sulfate films on cutaneous leishmaniosis in Balb/c mice has been studied. According to data and experiments available in Iran and some endemic countries about treatment of the disease by paromomycin, a new physical form of the drug was designed [drug film] and parasiticidal effects were evaluated in mice model. The base of the fi111is, ethyl cellulose and HPMC [hydroxy propyl Methyl Cellulose] contained paromomyein 15% and gentamicine 0.5%. In this regard female Balb/c mice were infected with 2X l0-6 L. major promastigotes [MRHO/IR/75/ER]. The mice were divided in three groups, of ten mice each. The placebo and test groups were received prepared placebo and drug films respectively. The remaining group, control received no treatment. The results indicated that utilization of this physical form of the drug in a mentioned period of time caused significant cure effects in the test group, so that 80% of Balb/c mice were cured at the end of the treatment period and there was no sign of cure in placebo and control groups. In general and because of good characters of the drug films and related results in animals, it is possible to use the new form of the drug in a human trial