Early gastrointestinal complications of stem cell transplant - results of prospective study at IRCH AIIMS, India

The study was conducted with the purpose of finding clinical profile of early gastrointestinal complications of stem cell transplant at this center. 70 consecutive subjects, who were subject to bone marrow transplant from October 2002 to September 2004, were prospectively studied. The gastrointestinal complications were followed in first 100 days of transplant and recorded in a pre-determined format. Study population comprised of 23 allo-transplant [with 3-non-myelablative procedures] and 47 auto-transplant subjects. Gastrointestinal complications included: nausea and vomiting occurred in 19 [82.60%], mucositis-20 [86.95%], diarrhea- 15% [65.12%], veno-occlusive disease [VOD] - 3 [13.04%] and acute pancreatitis- 1 [4.34%] in allo transplant group. Nausea and vomiting occurred 36 [76.59%], mucositis-46 [97.88%] diarrhea-39 [82.98%], VOD-5 [10.64%] in auto-transplant subjects. Acute graft versus host disease [AGVHD] involved gut in 3 and liver in 1 case of allo-BMT-group

Early infections in the stem cell transplant recipients at AIMS, New Delhi: a prospective study

The pattern of infections in neutropenic patients including those undergoing stem cell transplant in the west has changed but the same may not be the case in the developing countries as brought out through some earlier observations in some transplant centers in India. The department of medical oncology IRCH, AIIMS has been providing bone marrow transplant facility for over a decade now. It is one of the few bone marrow transplant units in northern India. A prospective study conducted on 70 consecutive bone marrow transplant subjects at this center was carried out with this perspective in view. To determine the frequency and pattern of infections in haemopioetic stem cell transplant [HSCT] recipients at this center in India