Effect of sucralfate on the in-vitro availability of some drugs

This work studied the effect of sucralfate on the in vitro release of some drugs which may influence their in vivo availability. Eight products including five conventional tablets [metformin, ketoprofen, norfloxacin, mebeverine and ranitidine] and three prolonged release tablets [metformin- R, theophylline SR and diltiazem] were chosen. In most of the cases, the presence of sucralfate decreased the drug release from their dosage forms. The influence of sucralfate on the in vitro drug release was ranked as follows: Ketoprofen > mebeverine > ranitidine > norfloxacin > metformin for conventional tablets and diltiazem > theophylline SR > metformin-R for controlled release tablets