Incidence of salivary gland tumors: a morphological study at pathology department of king edward medical university / Mayo hospital, Lahore

This study was conducted to see the incidence of the lesions of Salivary Gland. All the cases of salivary tissues submitted to the Pathology Department of King Edward Medical University were taken at the end of year [Jan 2005-Dec2005] and reanalyzed. There were 42 cases of salivary glands, out of which 19[45%] were males and 23[55%] were females. Age range was 12-72 years. Major number of cases [17] were from parotid, whereas 15 were from submandibular, 04 and 06 were from sublingual and minor salivary glands like palate respectively. There were 25[59.52%] pleomorphic adenoma, 01[2.3%], 01[2.3%], 04[9.5%], 07[16.6%] were monomorphic adenoma, lymphoepithelioma, mucoepidermoid carcinoma, adenoid cystic carcinoma respectively. Only 04[9.5%] cases showed chronic sialadenitis

Morphological evaluation of non neoplastic lesions of the thyroid gland

This study was conducted to see the frequency of non neoplastic lesions of thyroid glands in patients who underwent thyroid surgery at Mayo hospital, Lahore. It was a descriptive cross sectional study. It was a retrospective and prospective study commencing from Ist July 1999 to 30th June 2002 and was conducted at Pathology Department King Edward Medical University, Lahore. All thyroid samples submitted and reported at the Department of Pathology, King Edward Medical University, Lahore during a three year period commencing from Ist July 1999 to 30th June 2002 were included in this study. Out of the total number of 1136 thyroid surgical specimens, 855 specimens [75.26%] were shown to comprise of non-neoplastic lesions and were more common in females [77.2%] as compared to males [22.8%] giving a male to female ratio of 1:3.4. Regarding non neoplastic lesions maximum comprised of diffuse[74%] and multi nodular goiters [16%]. Others consisted of inflammatory conditions [5%], hyperplastic nodules[4%] and simple colloid filled cysts 1%. Inflammatory conditions included Hashimotos' thyroiditis [67.3%] deQuervain's thyroiditis [granulomatous thyroiditis] [16.3%], Lymphocytic thyroiditis [11.7%], and Riedel's thyroiditis[4.7%]. Non neoplastic thyroid lesions are more common than neoplastic lesions, especially in females. The frequency of diffuse colloid goiter was very high, while among inflammatory lesions Hashimotos' thyroiditis was the commonest lesion. Most of the cases of hypothyroidism were associated with iodine deficiency

Evaluation of nucleolar organizer region in normal brain tissues and astrocytic gliomas

This study was performed to evaluate the importance of Ag NORs in different grades of Astrocytic Gliomas. It was a descriptive study and was performed at Lahore General Hospital and Sheikh Zayad Hospital, Lahore. A total of 50 cases were collected within one year, and AgNOR staining was performed on 50 brain tumors and specimens were selected randomly. AgNOR was low, high, higher and highest in Astrocytic Gliomas, grade I [Pilocytic], II, III, and IV respectively as compared to normal brain tissue. AgNOR staining technique is a simple, quick and a cheap method to assess proliferative index in astrocytic Proliferative activity is a good parameter to assess the disease outcome in astrocytic glioma

Intra-cranial space occupying lesions a morphological analysis

The purpose of this study was to provide preliminary data on morphological patterns of intracranial space occupying lesions [ICSOL] in central Punjab province. This is a cross-sectional prospective study on 100 consecutive cases of intra-cranial space occupying lesions admitted to both the neurosurgery units of Lahore General Hospital, Lahore, Pakistan. The biopsy materials were examined histologically using paraffin sections. Eighty nine [89] patients had neoplasms, while eleven [11] had non-neoplastic lesions. Neuroepithelial tumours comprised 41% of all the neoplasms, followed by meningiomas being 23%, schwannomas 11% and metastatic tumours 6%. Males were affected slightly more than females [1.17:1]. Tuberculomas constituted 3% of the lesions. It was concluded that age and sex distribution were generally comparable to the other published literature. Similarly neuroepithehal tumours formed majority of the lesions. However meningiomas had a higher frequency as compared to the western literature; moreover tuberculomas should also be considered in the differential diagnosis of such lesions in this part of the world

Salivary gland tumors - a three years experience at King Edward medical college, Lahore

Salivary gland tumours make an important part of oral and maxillofacial pathology. Only few studies have been done in Pakistani population. The aim of this study was to describe morphological types of salivary gland tumours diagnosed at King Edward Medical College/ Mayo Hospital, Lahore during the years 1999-2001 and to compare their demographic data with those previously published. Material and This descriptive cross-sectional study was carried out at King Edward Medical College/ Mayo Hospital, Lahore. It reports 117 cases of salivary gland tumours diagnosed at Pathology Department during 1999-2001. Of the 128 specimens of salivary glands, 117[91.4%] were confirmed as salivary neoplasms. Out of them, 62.7% were benign and 37.6% malignant and a slight female predominance [58.1%] was found. The most common location was the parotid gland [65.8%] followed by minor salivary glands [19.6%]. Majority oft he t tumours was diagnosed during 3rd to 5 decades of life. Median age for benign tumours was 33 years [range 1-78] and a female predominance [58.9%] was seen again. Median age for malignant neoplasms was 45 years [range 9-70] with a female predilection [56.8%]. However, 4 out o f 5 patients with Warthin's tumour were men. Pleomorphic adenoma was the most frequent tumour [51.3%], followed by mucoepidermoid carcinoma [25.6%], adenoid cystic carcinoma [7.7]], Warthin's tumour [4.3%] and monomorphic adenoma [2.6%]. Two cases each of oncytoma and adenocarcinoma were recorded. Rare categories [single case each] of salivary tumours included lipoma, acinic cell carcinoma, basal cell adenoma, capillary haemangioma, metastatic carcinoma and non Hodgkin's lymphoma. The principal site of salivary tumours was the parotid gland and females were most affected. Pleomorphic adenoma was the most frequent finding. The results of this study are comparable with other studies

laboratory study of susceptibility of methicillin resistant staphylococcus aureus [MRSA]

To study the mode of infection, incidence of Methicillin resistant Staphylococcus aureus [MRSA] and their susceptibility against glycopeptides and Fucidic acid, so that awareness may be created for consultants against such notorious rapidly spreading bacteria and recommendation can be made for their prevention and control. Design: 350 S.aureus Strains were isolated from 1800 random clinical specimens. 135 MRSA out of these cultures were selected for determining susceptibility to Vancomycin, Teicoplanin 13 Fucidic acid. Place and Duration: The samples were processed in the Department of Pathology, King Edward Medical College, Lahore, during June 2000 to December 2000. The specimens from various infections suspected on clinical ground were processed by Standard methods and antibiotic susceptibility testing of all the 350 S.aureus and 135 MRSA isolates was done by using modified Kirby Bauer Disc diffusion technique. Result: Of 350 positive S.aureus cultures, 135 were found to be Methicillin resistant [38.5%] which showed susceptibility 96%, 94% and 86% to Vancomycin, Teicoplanin and Fucidic acid respectively. This study showed a high incidence of MRSA at Mayo Hospital Lahore. Glycopeptides and Fucidic acid were found to be valuable antibiotics against MRSA