Exploration and practice on construction of Tibetan medicine prescription information database and knowledge discovery / 中国中药杂志

This study aimed to explore the underlying framework and data characteristics of Tibetan prescription information. The information on Tibetan medicine prescriptions was collected based on 11 Tibetan medicine classics, such as Four Medical Canons(Si Bu Yi Dian). The optimal classification method was used to summarize the information structure of Tibetan medicine prescriptions and sort out the key problems and solutions in data collection, standardization, translation, and analysis. A total of 11 316 prescriptions were collected, involving 139 011 entries and 63 567 pieces of efficacy information of drugs in prescriptions. The information on Tibe-tan medicine prescriptions could be summarized into a "seven-in-one" framework of "serial number-source-name-composition-efficacy-appendix-remarks" and 18 expansion layers, which contained all information related to the inheritance, processing, origin, dosage, semantics, etc. of prescriptions. Based on the framework, this study proposed a "historical timeline" method for mining the origin of prescription inheritance, a "one body and five layers" method for formulating prescription drug specifications, a "link-split-link" method for constructing efficacy information, and an advanced algorithm suitable for the research of Tibetan prescription knowledge discovery. Tibetan medicine prescriptions have obvious characteristics and advantages under the guidance of the theories of "three factors", "five sources", and "Ro-nus-zhu-rjes" of Tibetan medicine. Based on the characteristics of Tibetan medicine prescriptions, this study proposed a multi-level and multi-attribute underlying data architecture, providing new methods and models for the construction of Tibetan medicine prescription information database and knowledge discovery and improving the consistency and interoperability of Tibetan medicine prescription information with standards at all levels, which is expected to realize the "ancient and modern connection-cleaning up the source-data sharing", so as to promote the informatization and modernization research path of Tibetan medicine prescriptions.

Prescription Regularity of The Four Medical Tantras-Scientific Implications of Ro Nus ZhurJes / 中国实验方剂学杂志

Ro Nus ZhurJes theory is the core content of Tibetan medicine,it can be divided into "taste performance"(Ro Yi Nus Pa) and "essential performance"(Ngo Bovi Nus Pa),and "taste performance" is divided into six tastes,eight properties,three tastes after digestion,seventeen effects and so on."Essential performance" is divided into eight kinds,including odor efficacy,sources efficacy,color efficacy,et al.Form bearing relationships that "taste performance" and "essential performance",the butt welding joins the three-factors and twenty characteristics of disease,it is the theoretical basis of Tibetan medicine from collection and processing,from formula to finished product. It is also the main method for the evaluation of drug performance by Tibetan medicine.Many classic Tibetan medicine prescriptions are compatible under the guidance of Ro Nus ZhurJes.However,at present,the research of Tibetan medicine mainly concentrates on the chemical composition and pharmacological mechanism.It is seldom studied from the Ro Nus ZhurJes theory of Tibetan medicine.It is difficult to find the core rules and effect of Tibetan medicine.Therefore,based on the ancient literature of Tibetan medicine,this paper combs the theory of Tibetan medicine property,explains the six tastes,three tastes after digestion,and seventeen effects of Tibetan medicine function in three-factors,twenty characteristics and other diseases attributes,in order to provide theoretical reference for the study of drug properties of Tibetan medicine.

A New Quantitative Method of Tibetan Medicine Property ——Construction of “Ro Nus ZhurJes” Vector Structural Model / 中国实验方剂学杂志

“Ro Nus ZhurJes” theory is the core content of Tibetan medicine property theory, and also the core compatibility law of Tibetan medicine. It takes six tastes of medicine as the surface medicinal property, three tastes after digestion by "three gastropyretie" as the inner medicinal property, eight properties and seventeen effects as the deep medicinal property, and its essential property is the special medicinal property, forming a multi-level medicinal property theory, but its internal structure still needs to be unified and sorted out, clinical practicability needs to be further improved. In this paper, literature mining, Tibetan medicine theory, vector structural model, K-means clustering analysis, Gephi 0.9.2 visualization and other methods were used to sort out the theory of Tibetan medicinal properties. It was found that the inherent structure of Tibetan medicine properties had the multi-dimensional structural characteristics of "seven medicinal properties+three characteristics", and that the same medicinal properties would overlap, while the opposite medicinal properties would offset and could be expressed by vectors. Therefore, the vector structural model of "Ro Nus ZhurJes" of Tibetan medicine was proposed in this paper. Taking twenty-five-flavor Yuganzi powder(skyu-ru-nyer-lnga) and 92 commonly used Tibetan medicine prescriptions as examples, the rates of single prescription with seventeen effects and multiple prescriptions acting on three factors were analyzed. The model analysis results were highly consistent with the clinical efficacy, and the main diseases were the same, which showed that this model had a high degree of fitting and interpretation. It could effectively and intuitively quantify the properties of Tibetan medicine prescriptions and uncover the complex hidden knowledge of Tibetan medicine theory. In the future, the vector structural model of "Ro Nus ZhurJes" will be applied to analyze the classical prescriptions of Tibetan medicine, and the fitting evaluation and modification optimization will be carried out continuously in order to improve the practicability of theory of Tibetan medicine property in the big data environment and provide methodological reference for the quantification of medicinal property of Tibetan medicine prescriptions.