Pattern of renal diseases among elderly Egyptians patients with acute or chronic reanal diseases in Ain Shams University and Nasser Institute Hospitals, Cairo, Egypt

This study among elderly renal Egyptian patients [n = 220] with only 20 of them were subjected to renal biopsy. Results showed: diabetic nephropathy in 28.2%, hypertensive nephrosclerosis 25.5%, UTI, cystitis and pyelonephritis in 6.8%, renal stones in 5.9%, obstructive uropathy in 7.6%, simple cysts in 4.5%, CRF of unknown origin in 13.1%, and others in 26.4%. DM and HTN were S related to kidney function tests and increase in elderly. Other cardiovascular risk factors and smoking are reported by previous workers to be HS related to renal diseases. Age was significantly related to GFR, BUN and Cr. but sex difference was not significantly related to renal diseases. Multiple myeloma, lupus nephritis, vasculitis and hepatitis B were all recorded in few numbers of elderly Egyptians. HCV was more common and more likely to cause renal diseases. Abdomino-pelvic ultrasound was confirmatory to clinical renal diseases diagnosis. Among patients [n = 20] biopsies showed focal necrotizing GN in 20%, membranous nephropathy in 50% and renal amyloidosis in 30%. CTIN was associated in some cases due to NSAID intake. Analgesic nephropathy was a common problem that might lead to ARF in some cases especially in the elderly. Ultrasound results among the biopsy group were confirmatory to clinical diagnosis.

Role of anticardiolipin antibodies in vascular complications in patients with chronic renal failure

This study included 30 patients with chronic renal failure [15 under regular haemodialysis and 15 under conservative management/or uraemia]. Ten healthy individuals were selected as a control group. Serum IgG anticardiolipin antibodies were determined by ELISA. The results showed that S. IgG anticardiolipin was significantly high in patients with chronic renal failure as compared with the control group [p < 0.01]. Six patients under haemodialysis [40%] and 2 patients under conservative management [13.4%] had positive anticardiolipin antibodies. Patients on haemodialysis with anticardiolipin IgG positivity showed a greater incidence of early thrombosis of anrteriovenous fistula with different varieties of vascular complications. S.IgG anticardiolipin levels in patients with vascular thrombosis were significantly higher than in those without vascular complications [P< 0.001]