RESUMO
A patient is described who presented with polyarthritis involving small and large joints of limbs with later onset of tremors affecting all four extremities. Investigations including genetic study confirmed the diagnosis of Wilson's disease (WD). The case highlights the importance of considering the possibility of WD in young patient presenting with repetitive unexplained joint symptoms with or without tremor.
Assuntos
Adulto , Artrite/etiologia , Artrografia , Degeneração Hepatolenticular/complicações , Humanos , Articulações/patologia , MasculinoRESUMO
OBJECTIVES: The association of low-dose aspirin use and gastro-intestinal bleeding is well described. However, the gastroduodenal mucosal changes associated with low-dose aspirin therapy have not been properly evaluated. We undertook a prospective, endoscopic study to evaluate gastro-duodenal mucosal lesions produced by low-dose aspirin. METHODS: Forty-seven patients with non-hemorrhagic cerebral infarct or transient ischemic attacks and normal upper gastrointestinal endoscopy were randomized to receive either enteric-coated (n=25) or plain (n=22) aspirin (150 mg/day). Follow-up endoscopy was done at 2, 4 and 8 weeks; gastro-duodenal mucosal lesions, if present, were scored. Forty-seven patients with hemorrhagic infarct who were not treated with aspirin served as controls. RESULTS: Twenty eight (60%) of 47 patients receiving aspirin had mucosal lesions; stomach alone was the most frequent site (32%), followed by both stomach and duodenum (23%). Frequency of mucosal changes in the stomach at 8 weeks (19%) was significantly lower (p<0.05) than those at 2 weeks (53%) and 4 weeks (55%). Coated (56%) and plain (63.6%) aspirin induced mucosal lesions with similar frequency. CONCLUSION: Administration of low-dose aspirin, either plain or enteric-coated, induces endoscopic gastro-duodenal mucosal lesions in a large majority of patients. The frequency of damage decreased after 8 weeks of therapy.
Assuntos
Adulto , Idoso , Anti-Inflamatórios não Esteroides/administração & dosagem , Aspirina/administração & dosagem , Infarto Cerebral/tratamento farmacológico , Relação Dose-Resposta a Droga , Esquema de Medicação , Endoscopia Gastrointestinal/métodos , Feminino , Seguimentos , Mucosa Gástrica/efeitos dos fármacos , Humanos , Mucosa Intestinal/efeitos dos fármacos , Ataque Isquêmico Transitório/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Valores de Referência , Medição de Risco , Fatores de Risco , Estatísticas não Paramétricas , Comprimidos com Revestimento EntéricoAssuntos
Adulto , Contratura/genética , Humanos , Ligação Genética , Masculino , Distrofias Musculares/genética , Cromossomo XRESUMO
The present study was undertaken to find out the profile of women undergoing medical termination of pregnancy (MTP) in Hospital, 1000 consecutive cases undergoing MTP at RG Kar Medical College and Hospital were studied. 95.6% cases were married and 4.4% cases were unmarried. In the whole series, 7.6% cases were teenagers though in unmarried group 90.9% cases were teenagers. In 56% of married group the monthly family income was more than Rs 500/- whereas majority in unmarried group had family income less than Rs 500/- per month. In the whole series, 44.4% cases were illiterate, 48.2% cases were educated up to primary school and only 7.3% cases up to high school and above. In the married group, 204 cases undergoing MTP with one living issue, 388 cases with 2 living issues and 396 cases with 3 living issues. In the whole series, 88% cases were 1st trimester MTP and 12% were 2nd trimester MTP cases, whereas in the unmarried group 72.7% cases were in the 2nd trimester, and 5.7% cases had history of previous MTP. Effective contraception was only 6% before MTP whereas it increased to 90.6% after MTP.