RESUMO
Objective: This study aimed to investigate the effect of preoperative administration of 5% dextrose on hyperalgesia induced by high-doses remifentanil
Design: Randomized, prospective
Setting: Operating room of a Wonkwang university hospital, South Korea
Subjects: One hundred and twenty-six patients undergoing laparoscopy-assisted distal gastrectomy
Intervention: Three groups received either 250 ml Hartmann's solution [HS] or 5% dextrose in HS for 1 hour before anesthesia and intraoperative remifentanil infusion. Group LHS received HS and 0.05 microg/kg/min remifentanil; group HHS received HS and 0.3 microg/kg/min remifentanil, and group HHD received 5% dextrose in HS and.3 microg/kg/min remifentanil
Main outcome measures: Mechanical hyperalgesia threshold at 1 hour after surgery, time to first postoperative analgesicrequirement, cumulative patient-controlled analgesia [PCA] volume containing morphine for 24 hours after surgery, and pain intensity using visual analog scale [VAS] for 24 hours after surgery were measured
Results: Mechanical hyperalgesia threshold of group HHS and HHD were significantly lower than that of LHS group. Cumulative PCA volume containing morphine for 24 hours after surgery and pain intensity for 12 hours after surgery of group LHS were significantly reduced than that of both HHS and HHD groups, both of which were not significant.Time to first postoperative analgesic requirement was longer in group LHS than in groups HHS and HHD, both of which were not significant
Conclusion: Preoperative intravenous administration of dextrose in patients undergoing laparoscopy-assisted distal gastrectomy didn't show any effects on hyperalgesia induced by high-doses remifentanil