RESUMO
Background and Objectives: The global incidence of dengue hasgrown dramatically in recent decades affecting children and young adults mainly intropical and subtropical countries.Dengue has a wide spectrum of clinicalpresentations, often with unpredictable clinical evalution and outcome. While mostpatients recover following a self-limiting non-severe clinical course, a smallproportion progress to severe disease, mostly characterised by plasma leakage with orwithout haemorrhage.Methods: It is a Prospective ,observational study including 150 serologicallyconfirmed Dengue fever in a tertiary care centre. The main objective was tostudy patterns of hepatopathy in dengue fever and to determine whether thepatterns of hepatic involvement correlate with clinical , laboratory profile andoutcome in Dengue fever according to WHO classification .Results: Younger age groups were found to be more prone tohepatopathy with 46.7 % of patients having hepatopathy(transaminases >3x UNL) belonging to ages 21-30 yrs. AST levelcorrelates maximum with severe Dengue ,followed by abnormal PTand APTT value .AST is more useful than ALT and AST:ALT Ratiois even more reliable indicator than using the values alone.Riskfactors which were statistically significant for mortality :PositiveTourniquet test, Abnormal CNS Examination, BleedingManifestations, and thrombocytopenia.Hepatic dysfunction Grade 3and 4 were not directly related to mortality.Interpretation and Conclusion: Even though hepatopathy does notcorrelate with the severity of disease directly, its significantassociation with warning signs ,thrombocytopenia and bleedingmanifestations make it very important factor to predict which subsetof patients will develop severe Dengue fever.Timely diagnosis ofhepatopathy in patients with dengue fever and its management mayimprove patient survival rate