RESUMO
The Sanskrit root of the term "yoga" is derived from "yuj," which means to, yoke, to unite, and to focus and direct one's attention. Yoga is a type of mind-body exercise that combines physical movement with a conscious emphasis on awareness of one's own breath, energy, and self. The second principle is that every individual is unique and every individual has different needs. Each person therefore has to have a practise that is adapted to their individual needs. The third principle involves the learner in the healing process by actively participating in their quest for health; healing occurs from within rather than from the outside. The individual's character and state of mind are crucial to healing, according to the fourth principle healing happens more quickly when someone is in a positive frame of mind whereas if someone is in a negative frame of mind, healing could take longer. To enhance quality of life, many people practise yoga as a supplemental therapy in addition to traditional medical therapies by holding a pose for a long period of time develops strength. Slow, deep breathing and movement warm up the muscles which will help to improve the health and wellness. Yoga has shown some encouraging outcomes as a complementary therapy for depression. Thus it has a number of potential advantages in all dimensions of health and disease
RESUMO
The objective of the study was to develop UPLC method for the determination of purity of Cefditoren Pivoxil in API and its validation. UPLC is a better technique than HPLC in terms of performance and speed, so it was selected. The method was developed using Acetonitrile and Ammonium Acetate buffer (pH 6.7) and Kromacil column C18 (50×2.1mm, 3.5μ) as a stationary phase at a flow rate of 0.25ml/min. Validation was done by linearity, precision, and robustness studies. The precision was found to be within the limits. The linearity studies indicated the drug obeys Beer’s law and revealed the specified range of linearity for drug was between 80μg/ml and 120μg/ml. The robustness was observed from the insignificant variation in the analysis by changes in flow rate, mobile phase ratio, wavelength, column oven temperature and pH. Forced Degradation study revealed the drug degraded initially by the influence of acid, alkali, and peroxide. Solution stability study showed the drug was not stable for more than 2 h at 25˚C but stable at 5˚C. It can be concluded that the proposed method was simple, precise, and robust and can be useful for determination of purity of Cefditoren Pivoxil in API by using UPLC.