Expression of AQP3 gene in chronic atrophic and chronic superficial gastritis patients

Most studies about aquaporin 3 [AQP3] in the gastrointestinal tract were carried out on both in vivo and in vitro. The role of AQP3-mediated water transport in human gastrointestinal tract is still unclear. Our aim in this study was to explore the expression of AQP3 gene in chronic atrophic gastritis [CAG] and chronic superficial gastritis [CSG] atients and to determine its possible function in the development of gastritis. Twenty-two outpatients diagnosed as CSG and 12 outpatients diagnosed as CAG were selected randomly. Ten cases of healthy individuals were selected as normal control group. In all cases, AQP3 gene expression of gastric mucosa was detected by fluorescence quantitative polymerase chain reaction [FQ-PCR]. The AQP3 gene expression was significantly higher in gastric mucosa of CSG and healthy individuals than that in CAG [P < 0.01]. However, there was no significant difference in the AQP3 gene expression between helicobacter pylori positive patients and helicobacter pylori negative patients [P > 0.05]. AQP3 expression might play certain role in the occurrence and development of gastritis

Observe the effect of recombinant human growth hormone on large area burn with severely inhalation injury / 中国基层医药

Objective Investigate the effect of recombinant human growth hormone on large area burn with severely inhalation injury. Methods Forty cases of large area burn with severely inhalation injury were divided randomly into two groups, 20 in control group and 20 in rhGH group. The indexes of nutritional status (including MAMC,Hb,total protein,albumin and so far),healing time of burn wound,and the time of mechanical ventilation were recorded and compared between two groups. Results The nutritional status showed no difference between two groups before treatment,and was significantly better in rhGH group after treatment.The healing time of autologous skin pulp grafting and donor site,the time of mechanical ventilation and the length of hospital stay were significantly shorter in rhGH group patients than control group.Conclusion rhGH can enhance the wound healing rate,improve the nutritional status of patients with mechanical ventilation,shorten the time of mechanical ventilation,and decrease the complications of burn.