Monoclonal gammopathy, a three year study on paraproteinemias

Sera from 22 patients [16 males + 6 females] with electrophoretically and immunologically secured diagnosis of monoclonal gammopathy were tested for various biochemical parameters. The final clinical diagnosis showing gamma-globulinemias in them was in the order of multiple myeloma [MM] 20 nos, Waldenstrom macroglobulinemia [MW] 1 no. and light chain disease [LCD] 1 no. The incidence of plasma cell neoplasm among Saudies is not very rare. The predominant type is IgG myeloma [74%] with a kappa to lambda ratio of 2: 1. Bence Jones Proteinuria is comparativly less common. Elevated levels of gamma glutamyl transpeptidase [GGT] in a good number of patients indicate the high occurrence of hepatic involvement in such patients

three year study of the electrophoretic patterns of serum proteins with special reference to various globulinopathies in Saudis

Human sera comprising 545 specimens spread over a period of three years were analyzed electrophoretically for proteins. Only 159 samples [29%] exhibited abnormal serum protein patterns. They were in the order of inflammatory disorders [acute/chronic], 60 [37.7%], Polyclonal gammopathies,48 [30.1%], Cirrhosis, 22 [13.8%], Monoclonal gammopathies, 22 [13.8%], Agammaglobulinemia, 3 [1.9%], Nephrosis, 2 [1.2%], Protein-losing enteropathy, 1 [0.6%], Low-alpha 1 -antitrypsin, 1 [0.6%], Inflammatory diseases of various nature, therefore, constitute the major serum protein abnormalities in Riyadh. Moreover, their occurrence varies with age, sex and climatic conditions as elsewhere in the world