Study of vitamin d level in cirrhotic hcv patients before and after transplantation

Background: chronic hepatitis C is a common condition. Transfusion of blood or blood-related products was one of the main routes of HCV transmission. Furthermore, nosocomial infections represent a key source of infection, particularly in some of the high-prevalence countries [such as Egypt, Pakistan and Eastern Europe]. In general, prevalence increases with increasing age until peak prevalence at 55-64 years in most regions. At least six HCV genotypes are known, Genotype 4 frequency is the highest from Central Africa to the Middle East. Worldwide people infected with HCV are at an increased risk of developing serious hepatic complications including cirrhosis and hepatocellular carcinoma

Aim of the Work: the aim of this work is to study vitamin D level in post HCV liver cirrhosis patients before and six months after liver transplantation in addition to chronic HCV patients without cirrhosis

Patients and Methods: this prospective case control study was conducted on 25 patients. 15 of them with liver cirrhosis due to chronic hepatitis C virus evaluated before and six months after liver transplantation in addition to 10 chronic HCV patients without cirrhosis as control group. Liver cirrhosis or transplantation patients were recruited from Ain Shams specialized hospital liver transplantation unit and chronic HCV patients without cirrhosis were recruited from hepatology outpatient clinic of Ain Shams university hospital in the period from February 2017 to November 2017. Symptoms suggestive of liver disease [e.g. jaundice, bleeding tendency, increased abdominal girth]

Results: this study was conducted on 25 patients. 15 of them with liver cirrhosis due to chronic hepatitis C virus evaluated before and six months after liver transplantation in addition to 10 chronic HCV patients without cirrhosis as control group. Group I: Consists of 15 [60%] patients with post HCV liver cirrhosis before liver transplantation. They were 13 males [86.6%] and 2 females [13.3%]. Their mean age was 50.53 +/- 4.52. Group II: Consists of the same patients of group I evaluated six months post liver transplantation. Group III: Consists of 10 [40%] patients with chronic HCV without cirrhosis. They were 6 males [60%] and 4 females [40%]. Their mean age was 53.0 +/- 8.46

Conclusion: this study concluded that vitamin D deficiency is prevalent among patients with liver cirrhosis. Liver transplantation improves vitamin D level but not to the recommended normal level i.e. vitamin D deficiency or insufficiency can persist after transplantation

New ellagic acid derivative from the fruits of heat-tolerant plant Conocarpus lancifolius Engl. and their anti-inflammatory, cytotoxic, PPAR agonistic activities

Conocarpus lancifolius [Combretaceae], " ÏãÓ ÓäÇäí " in Arabic, is distributed in Riyadh, Saudi Arabia. It is a heat-tolerant Saudi medicinal plant, demonstrates prominent antidiabetic potential and the fruit extract fruits showed cytotoxicity against MRC-5 cancer cell line, as well as prominent antiprotozoal and antibacterial activities. The objective of this study is to isolate the compounds and evaluate the anti-inflammatory, cytotoxic, PPAR agonistic and antioxidant activities of extracts and pure constituents from C. lancifolius. A new trimethoxyellagic acid derivative 1 and two compounds, kaempferol 3-O-rutinoside 2 and beta-sitosterol glucoside 3 were isolated from the fruits of Conocarpus lancifolius, a heat-tolerant plant. Compound 2 showed strong dual activation for PPAR alpha and PPAR gamma with 2.6 fold increment in PPAR alpha activity, while 2.2 fold increment in PPAR gamma at 25 micro g/mL. This is first report on isolation and screening of different biological activities of extract and pure constituents from fruits of C. lancifolius

Isolation of flavonoids from Delonix elata and determination of its rutin content using capillary electrophoresis

Delonix elata [L.] Gamble [Fabaceae] is an important, traditionally used plant in Saudi Arabia. It is used to relieve rheumatic pain, flatulence and the seeds are employed as purgatives. The aim of the present study was to isolate chemical constituents of the n-butanol fraction [BF] of D. elata and to find out, by capillary electrophoresis [CE], percentage of rutin present in this BF. Three quercetin glycosides and one kaempferol rutinoside were isolated from the BF of aerial parts of D. elata; namely, Quercetin 3-O-rutinoside-7-O-glucoside [1], Quercetin 3,7-diglucoside [2], Quercetin 3-0-rutinoside [RUT] [3] and Kaempferol 3-0-rutinoside [4]. Rutin, an active constituent has been reported to possess good pharmacological as well as therapeutic potentials. A sensitive and rapid procedure for quantitative determination of RUT by capillary electrophoresis was developed and its content was found to be 7.349 mg/gm, relative to n-butanol fraction and 18.373 mg%, relative to the dry powder of D. elata. The method could be recommended for approval and use in the pharmaceutical and food industries

satirical programme in Arab satellite channels and the adolescents attitude towards it

Problem: With studies rarity which take the satric programme as a new programme in Egypt and exposure the politic issue, we can determined the Study problem in this main statment [the satric programme in Arabic satellite channel and the adolescents attitude towards it

Importance: The study related with an important strip in the society isadolescents strip, and rarity of satirical programs and the newly appearance in EgyptAnd addressed political issues

Aims: This study aims to Know what's adolescents attitude towards the satric programme in Arabic satellite channel and the

Study Kind: This study is adscription study

Methods: Survey Method

Tools: Content Analysis Form, Questionnaire Form, and Attitude Scale

Results: The program used vernacular language, The template used in program is direct talk, Presidential elections were at the forefront of the issues by 16%, The sample watched the program for Entertainment by 64.2% and Corruption revealed by 49.7. The programe present Political information by 42.5% and About Army Men by 13%, The study demonstrated verify partially the first hypothesis, which states on the presence of a statistically significant correlation between the exposure of adolescents study sample programs sarcastic and attitudes towards it, The study showed that there were no statistically significant differences in the attitude of adolescent males and females towards satirical programs through exposure to them in favor of male teenagers and from here we can say that the hypothesis has not been achieved, and The study demonstrated a statistically significant differences between age and the trend toward programs Sarcastic in favor of older teenagers, so we can say that the hypothesis has been achieved parthly

Cytotoxic flavonoid glycosides from rapistrum rugosum l

Five flavonoid glycosides were isolated from the-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 'H- and [13]C-NMR spectra [DEPT] with 2D NMR as quercetin-3-[9-a-L-rhamnopyranoside [1], quercetin-3-<9-/?-D-xyloside [2], quercetin, 3-0-a-L-arabinopyranoside, 7-0-a-L-rhamnopyranoside [3], kaempferol 3-0-a-L-arabinopyranoside, 7-0-a-L-rhamnopyranoside [4] and rutin [5]. The SRB cytotoxic assay was used to investigate the antitumor activities of "-butanol extract, compound 3 and its hexaacetate 3a, for the first time. Compounds 3 and 3a showed cytotoxic activity against the human cancer cell line, namely, HepG2 [hepatocellular carcinoma cell line] with IC[50] [concentration of compound required to reduce cell survival by 50%] 0.86 microg/mL and 3.50 microg/mL, respectively. These results proved that compound 3, the major flavonoid of the ft-butanol soluble fraction, has significant cytotoxic activity compared with the standard antitumor drug doxorubicin [0.60 microg/mL]

Functional properties of whey protein in bread in the presence of glucose oxidase and ascorbic acid

The main objective of the present study was to determine the influence of whey protein on the final bread product characteristics and to investigate the effect of different treatments for improving its functionality. The specific objectives were to study the functional properties of whey protein in bread making system, determine the baking performance of whey protein in the presence of glucose oxidase at different levels [200-300 GoDu/kg], determine the baking performance of whey protein in the presence of ascorbic acid [20ppm] and determine the functional properties of whey protein in the present of both glucose oxidase and ascorbic acid. In this study 12 treatment as well as control samples were prepared using 2 levels of whey protein [2% 4%] and 2 levels of glucose oxidase [200-300 GoDu/Kg] glucose oxidase and ascorbic acid at [20 ppm]. The products were subjected to chemical, objective, organoleptic and nutritive value evaluations. Results showed that bread volume increased upon the addition of [2%] whey protein and ascorbic acid [20ppm] while decreased in the addition of whey protein at [4%] and ascorbic acid at level [20 ppm]. Weight is increased upon the addition of whey protein at level [4%] with ascorbic acid at level [20 ppm] and upon using glucose oxidase at level [300 GoDu/Kg]. Degree of staling decreased upon using the level of [2%] whey protein. Results showed that with and without using glucose oxidase there was a decrease in moisture content and increase in protein, fat and ash contents at the level of [4%] whey protein in the presence of glucose oxidase at high level. Sensory evaluation results indicated that samples prepared with [2% whey protein + 20 ascorbic acid + 200 glucose oxidase] and [4% whey protein + 20 ascorbic acid +300 glucose oxidase] had better color and taste compared to the other prepared samples. The present study recommended the beneficial use of whey protein to fortify bakery products in the presence of glucose oxidase [300 GoDuIKg] and ascorbic acid [20 ppm] to maintain good quality

Impact of a psycho-education intervention on insight of hospitalized schizophrenic patients

Severely impaired insight is one of the main characteristics of psychotic disorders that present a major obstacle for treatment. Traditionally, insight has often been viewed as a simple or unitary construct. Recently, it is considered as a complex phenomenon with multiple components. A general lack of insight is widespread and very common in many patients with schizophrenia. Psycho-education is a form of mental health intervention which focuses on educating patients about their disorders, emotional responses, and treatments, as well as supporting positive coping mechanisms. The main purpose of this study was to determine the impact of psycho-education intervention on insight development among hospitalized schizophrenic patients. A structured frame of psycho-education intervention was developed by the researchers. The intervention aimed at increasing patients' awareness about their mental disorder, their symptoms as well as its attribution, the social consequences of mental disorder and the achieved effects of medication. Before the implementation of psycho-education intervention, the total Scale to Assess Unawareness of Mental Disorder [SUMD] mean scores for current awareness and attribution were 13.78 +/- 2.95 for the intervention group and 15.04 +/- 2.73 for the control group [mild to moderate degree lack of insight]. These results changed after the implementation of the psycho-education intervention to 7.96 +/- 2.81 and 15.67 +/- 2.39 respectively, with a statistical significant improvement [t=14.731, P=0.00] on the part of the intervention group. This was also true when comparing the two groups' SUMD subscale mean scores

Clinical and radiographic evaluation of autologous platelet gel in the management of osseous defects in adult periodontitis

The present study was conducted in order to evaluate the use of "platelet gel" - the autologous source of growth factors - in management of osseous defects in patients with adult periodontitis. Twenty periodontal osseous defects in ten patients suffering from moderate to advanced adult periodontitis were treated in this study [split mouth design]. One defect from each patient was treated surgically with placement of platelet gel, while the other was treated by mucoperiosteal flap without placement of gel. All patients were subjected to thorough clinical examination in selected sites, including; plaque index, papillary bleeding index, probing pocket depth and probing attachment level. All these clinical parameters were taken prior to surgery and at 3, 6 and 9 months post-surgically. These patients were also subjected to radiographic and densitometric evaluations before and at 3, 6 and 9 months after surgery, in order to record the changes in bone height of selected osseous defects using the "Schei method" and also to evaluate the changes in bone density in these defects using a densitometer. The results of the present study showed the following: Platelet gel, used in this study as an autologous source of growth factors, was well tolerated by human periodontal tissues. Both treatment modalities showed significant reduction in plaque index, papillary bleeding index probing pocket depth and probing attachment level between pre- and post-surgical follow up periods. Throughout the follow up period, no significant difference was found with respect to plaque index on comparing test and control sites, while significant difference was detected at 3, 6 and 9 months post-surgically with respect to papillary bleeding index and probing attachment level, and at 6 and 9 months for probing pocket depth in the favor of the test sites. Radiographic analysis revealed improvement in bone height between pre- and post-surgical follow up periods in both test and control sites, but this improvement was not significant. On comparing test and control sites, it was found that test sites showed greater increase in bone height, particularly at 6 and 9 months post-surgically. However, also this increase was not significant. An improvement in mineral content was detected in both test and control sites throughout the observation periods. A statistically significant difference was detected between test and control sites at 3, 6 and 9 months post-surgically with the test sites exhibiting greater improvement