RESUMO
Several factors in changes renal disease [esrd] enhance protein catabolism and increase protein requirements. The relative important of nutritional markers in relation to haemodialysis process in patients with chronic renal failure [crf] is still under investigation. This study was designed to evaluate the effect of recombinant human erythropoietin [r-huepo] therapy on hemoglobin [Hb] level and some nutritional markers [serum albumin, insulin like growth factor-1 [IGF-1] and serum leptin] in patientys on regular haemodialysis. Patients were subdivided into 2 group, the first group receiving r-huepo and the second group not receiving r-huepo. All parameters were studied at the start of study after 3 months. Recombinant human erythropoietin therapy combined with haemodialysis caused significant increase in h[b], albumin and igf-1 level after 3 months, while regular haemodialysis caused significant increase in h[b] and albumin only. The increases were more marked in the group receiving r-huepo. A significant positive correlation was found between both body mass index [bmi] and triceps skin fold [tsf] and lepton. In conclusion, r-huepo therapy can accelerate improvements in nutritional status and the h[b] level in patients on regular haemodiaysis