Cassia Angustifolia Primed ASCs Accelerate Burn Wound Healing by Modulation of Inflammatory Response

Background@#Thermal traumas impose a huge burden on healthcare systems. This merits the need for advanced but cost-effective remedies with clinical prospects. In this context, we prepared a regenerative 3D-construct comprising of Cassia angustifolia extract (SM) primed adipose-derived stem cells (ASCs) laden amniotic membrane for faster burn wound repair. @*Methods@#ASCs were preconditioned with SM (30 µg/ml for 24 h), and subsequently exposed to in-vitro thermal injury (51 °C,10 min). In-vivo thermal injury was induced by placing pre-heated copper-disc (2 cm diameter) on dorsum of the Wistar rats. ASCs (2.0 × 105) pre-treated with SM (SM-ASCs), cultured on stromal side of amniotic membrane (AM) were transplanted in rat heat-injury model. Non-transplanted heat-injured rats and non-heat-injured rats were kept as controls. @*Results@#The significantly upregulated expression of IGF1, SDF1A, TGFβ1, VEGF, GSS, GSR, IL4, BCL2 genes and downregulation of BAX, IL6, TNFα, and NFkB1 in SM-ASCs in in-vitro and in-vivo settings confirmed its potential in promoting cell-proliferation, migration, angiogenesis, antioxidant, cell-survival, anti-inflammatory, and wound healing activity. Moreover, SM-ASCs induced early wound closure, better architecture, normal epidermal thickness, orderly-arranged collagen fibers, and well-developed skin appendages in healed rat-skin transplanted with AM+SM-ASCs, additionally confirmed by increased expression of structural genes (Krt1, Krt8, Krt19, Desmin, Vimentin, α-Sma) in comparison to untreated-ASCs laden-AM transplanted in heat injured rats. @*Conclusion@#SM priming effectively enabled ASCs to counter thermal injury by significantly enhancing cell survival and reducing inflammation upon transplantation. This study provides bases for development of effective combinational therapies (natural scaffold, medicine, and stem cells) with clinical prospects for treating burn wounds.

Antimicrobial activity of Er, Cr: YSGG and Ultrasonic on E. faecalisbiofilm in the mesial root canal systems of lower molars / Atividade antimicrobiana de Er, Cr: YSGG e Ultrassônico no biofilme de E. faecalis nos sistemas de canais radiculares mesiais de molares inferiores

The internal topography of the root canal is complex, especially for the permanent molar's mesial root. In response to such issues, improved irrigation techniques have been created, which use laser pulses to agitate fluids and improve microbial deposit removal. Objective: To assess the effectiveness of the Er,Cr:YSGG laser with a wavelength of 2,780 nm via photon-induced photoacoustic streaming (PIPS) protocol which agitated of 2% chlorohexidine (CHX) in removing mature Enterococcus faecalis (E. faecalis) biofilm in root canal systems of lower molars. Material and Methods: The mesial roots of lower first and second molars were separated and inoculated with E. faecalis bacterial suspension for 30 days. The roots were irrigated with CHX, some of them were agitated with a passive ultrasonic device (PUI), while the other roots were agitated by an Er,Cr:YSGG laser in PIPS at 60 µs/pulse, 5 Hz, (0.25, 0.5, 0.75, and 1) W. An atomic force microscope (AFM) was used as a new method to get the results in the isthmus area; the obtained results from each group were compared with each other. Results: Based on the AFM and SEM analyses, laser and ultrasonic activation groups showed higher antimicrobial efficacy than the conventional syringe irrigation group (P<0.05). Conclusion: Based on the investigation's findings, the activation of 2% CHX solution by Er,Cr:YSGG laser in PIPS and PUI offers better mature bacterial biofilm removal in the mesial root of lower human molars than the same irrigant with the SI technique (AU)

A topografia interna do canal radicular é complexa, especialmente para a raiz mesial do molar permanente. Em resposta a esses problemas, foram criadas técnicas aprimoradas de irrigação, que utilizam pulsos de laser para agitar fluidos e melhorar a remoção de depósitos microbianos. Objetivo: Avaliar a eficácia do laser Er,Cr:YSGG com comprimento de onda de 2.780 nm via protocolo de streaming fotoacústico induzido por fótons (PIPS) que agitou clorohexidina a 2% (CHX) na remoção de Enterococcus faecalis maduro (E. faecalis) biofilme em sistemas de canais radiculares de molares inferiores. Material e Métodos: As raízes mesiais de 28 primeiros e segundos molares inferiores foram separadas e inoculadas com suspensão bacteriana de E. faecalis por 30 dias. As raízes foram irrigadas com CHX, sendo algumas delas agitadas com aparelho ultrassônico passivo (PUI), enquanto as demais raízes foram agitadas com laser Er,Cr:YSGG em PIPS a 60 µs/pulso, 5 Hz (0,25, 0,5, 0,75 e 1) W. Um microscópio de força atômica (AFM) foi utilizado como um novo método para obter os resultados na área do istmo; os resultados obtidos de cada grupo foram comparados entre si. Resultados: Com base nas análises de AFM e SEM, os grupos de ativação por laser e ultrassom apresentaram maior eficácia antimicrobiana do que o grupo de irrigação com seringa convencional (P<0.05). Conclusão: Com base nos achados da investigação, a ativação da solução de CHX a 2% pelo laser Er,Cr:YSGG em PIPS a (60 µs/pulso, 5 Hz, 0,75 W) oferece melhor remoção de biofilme (AU)

Estimation of Cardiac Doses during Breast Cancer Radiotherapy in Pakistan

This study aims to estimate the absorbed radiation doses to the heart during breast cancer treatment with conventional radiotherapy. The cardiac doses of eighty-three patients during breast cancer radiotherapy were estimated, with fifty-two patients having left breast cancer and thirty-one having right breast cancer. For left breast cancer patients, a Treatment Planning System (TPS) was used to estimate the percentage volume of the heart receiving 20 Gy (V20%), 25 Gy (V25%), 30 Gy V30%), and 40 Gy (V40%). The Maximum Heart Distances (MHD) within the radiation field for left breast cancer patient sand the Minimum Distance of Heart from the Posterior Border of the Radiation Field (MDHF) for right breast cancer patients were measured. Through TPS, the mean dose to the 5% and 10% heart volumes, the lowest dose (Dmin), the maximum dose (Dmax), and the average dose (Davg) of the heart for all patients with left and right breast cancer were also calculated. For patients with left breast cancer, higher mean values of V20 (%), V25 (%), V30 (%), and V40 (%) were estimated and a direct correlation between MHD and Davg was observed. The relationship between MDHF and Davg in patients with right breast cancer was observed to be linear but with a negative slope. Patients undergoing radiotherapy for left breast cancer receive higher doses and are therefore recommended for assessment of cardiac complications during follow-ups.

Meta-analysis of incidence and outcomes of life-threatening arrhythmias in takotsubo cardiomyopathy

Background: Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is a transient heart condition that clinically resembles an acute coronary syndrome. This study aims to assess the incidence of life-threatening arrhythmias in patients with Takotsubo cardiomyopathy and evaluate the outcomes of patients with life-threatening arrhythmias (LTAs) in Takotsubo cardiomyopathy compared with those without LTA. Methods: We comprehensively searched the PubMed, Google Scholar, and Embase databases from inception to February 2021. The primary aim of the study was to determine the incidence of LTAs in TC patients. Other outcomes of interest were the odds of in-hospital, long-term mortality, and cardiogenic shock (CS) in TC patients with LTAs versus those without LTAs. For all statistical analyses, ReviewManager and MedCalc were used. Results: Eighteen studies were included in this study involving 55,557 participants (2,185 with LTAs and 53,372 without LTAs). The pooled incidence of LTAs in the patients of TC was found to be 6.29% (CI: 4.70 e8.08%; I2 ¼ 94.67%). There was a statistically significant increased risk of in-hospital mortality (OR ¼ 4.74; CI: 2.24e10.04; I2 ¼ 77%, p < 0.0001) and cardiogenic shock (OR ¼ 5.60; CI: 3.51e8.95; I2 ¼ 0%, p < 0.00001) in the LTA group versus the non-LTA group. LTA was not associated with long-term mortality (OR ¼ 2.23; CI: 0.94e5.28; I2 ¼ 53%, p ¼ 0.07). Conclusion: The pooled incidence of life-threatening arrhythmias in the patients of TC was found to be 6.29%. In the group of TC patients with LTAs, the odds of in-hospital mortality and CS, was higher than in the TC patients without LTAs.

Nutritional anemia types and management

Background: Nutritional anemia or anemia due to dietary causes is the most common form, yet, it is the easiest to manage compared to other forms of anemia. Some of the most common nutritional deficiencies are iron, cobalamin, folate, and also other elements like copper. Anemia due to diet is mostly asymptomatic in the initial phase until the stores are depleted, which can take a few months to several years, depending upon the cause

Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE fromJanuary 1987 toMarch 2017. The following search terms were used: nutritional anemia, dietary anemia, iron deficiency anemia, cobalamin deficiency, folic acid deficiency anemia, dietary anemia treatment

Aim of the work: In this study we aimed at understanding the different types of anemia caused as a result of dietary deficiency. We also briefly studied their presentation, pathophysiology, and treatment

Conclusion: Various causes of anemia, presentations, and complications associated with the different types of nutritional anemia, which is considered the easiest to treat and manage. Most cases are due to an underlying occult disorder rather than simple dietary insufficiency. Diagnosis can be more difficult in some cases, and require thorough history and investigations and integration to reach to an accurate conclusion and consequently treat the underlying cause

Molecular subtypes among patients with breast cancer

Objective: To evaluate the estrogen receptor [ER], progesterone receptor [PR] and HER-2 receptor expression in breast cancer patients

Design: A Retrospective Study

Setting: Oncology Department, King Hamad University Hospital, Bahrain

Method: All women with a confirmed diagnosis of breast cancer via biopsy from 2010 to 2016 were reviewed. The following were documented: age, type, and stage of cancer

Result: Eighty-nine patients were included in the study. A total of one hundred and two patients were diagnosed with breast cancer based on biopsy results; thirteen patients were excluded due to the unknown stage and/or grade. The mean age was 53.9 years. The majority of cases were infiltrating ductal carcinoma [IDC], 82 [92%]. The most common molecular subtype detected in the study was Luminal B [ER+, PR+, HER2+], 29 [32.6%] of the study population. Nine [10%] had an unknown grade, and 8 [8.9%] had unknown stage were excluded from the analysis

Conclusion: Many patients were lost to follow-up. More effort is needed to reduce the proportion of unknown stages and grades of breast cancer cases. Further research is advised to evaluate the prognosis of breast cancer patients in Bahrain due to the high incidence in the Gulf Cooperation Council [GCC]

Assessing awareness about diabetes mellitus among attendees of primary health care centers, Makkah, Saudi Arabia

Background: diabetes is well studied in Saudi Arabia; however, there seems to be little research in the area of awareness, education and health care delivery

Objectives: to assess the awareness about diabetes mellitus among attendees of primary health care centers, Makkah, Saudi Arabia

Subjects and Methods: a cross-sectional study was conducted among a representative random sample of adult attendees of primary health care centers [diabetic and non-diabetics], Makkah Al-Mokkaramah, the kingdom of Saudi Arabia during the study period [1-31 November, 2016]. An Arabic self-administered questionnaire was used for data collection. It includes 31 questions with sections of demographic data, community awareness regarding diabetes definition, risk factors, signs and symptoms, and complications community awareness regarding diabetes prevention

Results: the study included 662 adult patients. Approximately one-third of them [32.2%] aged 60 years or more. Females represent 51.1% of them. More than one-fifth of them [21%] were university graduated whereas 6.3% were illiterates. Prevalence of diabetes among the participants was 33.7% and majority of them [97.9%] had family history of diabetes. The most frequent sources were mass media [57.4%], health sector [29.9%] and educational sector [10.6%]. Overall sufficient awareness regarding diabetes mellitus was reported among majority of the participants [91.2%]. Among studied factors, only marital status and income were significantly associated with sufficient awareness

Conclusion: population in Makkah AL-Mokkaramah has enough knowledge of the general knowledge of diabetes regarding risk factors, symptoms, etc. However, they are not very well aware of the diabetes associated secondary complications

Assessment of knowledge, attitude and practice toward acne vulgaris among community in Jeddah City, 2016

Background: acne vulgaris is the most common skin condition seen by the dermatologists. It is a chronic inflammatory disease of pilosebaceous unit characterized by seborrhea, comedones, papules, pustules, nodules, cysts and in some cases scars and keloids, which persist for rest of the life

Objectives: the present work aimed at evaluating the level of awareness, Attitude and Practice toward acne vulgaris in Jeddah city

Methods: a cross sectional analytical questionnaire based study was carried out among the general population in Jeddah city. This study started in the year [2016] and composed of 461 subjects. The mean age of citizens was 28, 82. To assess citizens' demographic factors and beliefs about acne vulgaris, consenting citizens completed an anonymous online questionnaire. The data was entered and analyzed using SPSS version 20

Results: The sample is consisted of 65, 8% women and 34, 2% men. Among the respondents 7, 7% reported suffering from acne vulgaris and 13, 6% confirmed having a history of acne vulgaris illness in their family. The results of the study showed that 153 [34, 8%] subjects had weak knowledge related to the disease, 260 [59, 1%] subjects had average level of knowledge while only 27 [6, 1%] subjects had good knowledge regarding acne vulgaris. There was a statistical significant association between gender, educational level and the level of awareness about acne vulgaris

Conclusion: acne vulgaris is a disease that is potentially controllable but that cannot be cured. Education still be important overall the treatment of the patients

Synthesis, pharmacological screening and computational analysis of some 2-[l-Indol-3-yl]-A [[un]substituted phenylmethylidene] acetohydrazides and 2-[l-Indol-3-yl]-7V[[un]substituted benzoyl/2-thienylcarbonyl] acetohydrazides

The undertaken research was initiated by transforming 2-[l-Indol-3-yl]acetic acid [1] in catalytic amount of sulfuric acid and ethanol to ethyl 2-[l-Indol-3-yl]acetate [2], which was then reacted with hydrazine monohydrate in methanol to form 2-[l-Indol-3-yl]acetohydrazide [3]. Further, The reaction scheme was designed into two pathways where, first pathway involved The reaction of 3 with substituted aromatic aldehydes [4a-o] in methanol with few drops of glacial acetic acid to generate 2-[l-Indol-3-yl]-AD-[[un]substitutedphenylmethylidene]acetohydrazides [5a-o] and in second pathway 3 was reacted with acyl halides [6a-e] in basic aqueous medium [pH 9-10] to afford 2-[l-Indol-3-yl]-AD-[[un]substitutedbenzoyl/2-thienylcarbonyl]acetohydrazides [7a-e]. All The synthesized derivatives were characterized by IR, EI-MS and !H-NMR spectral techniques and evaluated for their anti-bacterial potentials against Gram positive and Gram negative bacterial strains and it was found that compounds 7a-d exhibited antibacterial activities very close to standard Ciprofloxacin. The synthesized derivatives demonstrated moderate to weak anti-enzymatic potential against oc-Glucosidase and Butyrylcholinesterase [BChE] where, compounds 7c and 5c exhibited comparatively better inhibition against these enzymes respectively. Compounds 7a, 7d and 7e showed excellent anti-enzymatic potentials against Lipoxygenase [LOX] and their IC[5]o values were much lower than the reference standard Baicalein. Enzyme inhibitory activities were also supported by computational docking results. Compounds 5c, 7a, 7b and 7c also showed low values of % hemolytic activity as well, showing that these molecules were not toxic, indicating that these molecules can be utilized as potential therapeutic agents against inflammatory ailments

Prevalence and risk factors of plantar fasciitis among patients with heel pain attending primary health care centers of Makkah, Kingdom of Saudi Arabia

Background: Plantar fasciitis is the most common cause of heel pain in adults seen in primary care. Extended standing and running frequently cause strain on the plantar fascia. Plantar fasciitis outcome is generally good, about 80 percent of people have no symptoms after one year

Objectives: To determine prevalence rate and risk factors of plantar fasciitis in primary health care settings

Methods: A cross-sectional study was conducted on 270 patients with heel pain attending five randomly selected primary health care centers. An interview questionnaire was structured to recognize the socio-demographic data, medical history of heel pain and independent risk factors for plantar fasciitis. Diagnosis was based on history and clinical examination

Results: The prevalence of plantar fasciitis among 270 patients was 57.8%. 88 [56.4%] of them were males, 104 [66.7 %] were obese, 91 [58.3 %] were wearing inappropriate shoes and 140 [89.7 %] had sedentary lifestyle. Logistic regression showed that sedentary lifestyle is the most significant variable associated independently to plantar fasciitis [OR = 38.371; 95% CI: 5.411- 272.110 p 0.000]

Conclusion: Plantar fasciitis is very common in primary health care settings. Obesity, sedentary lifestyle, wearing inappropriate shoes, frequent running and long standing were shown to be risk factors

Low dose albumin for the prevention of renal impairment following large volume paracentesis in cirrhosis

Objectives: To evaluate the effect of low dose Albumin i.e. 4 grams per litre of ascitic fluid after large volume paracentesis [LVP] for the prevention of paracentesis induced circulatory dysfunction [PICD] related renal impairment in cirrhosis. Methods: Case records of all patients with cirrhosis who underwent LVP from January 12th, 2011 till December 29th, 2013 were reviewed. Patients were excluded if they had spontaneous bacterial peritonitis, creatinine >1.5 mg/dl, hepatoma or if volume of ascitic fluid removed was <5 litres. Data including age, gender, cause of cirrhosis, CTP score and volume of ascitic fluid drained were noted. In addition serum creatinine and serum sodium at baseline and one week post paracentesis were recorded. Results: Two hundred and fourteen patients with cirrhosis underwent LVP during the study period. One hundred and thirty nine patients met the inclusion criteria and were analyzed. Patients were divided into two groups based on the amount of albumin given. The amount of albumin given was 25 grams and 50 grams while the volume of ascitic fluid removed were 6.2+/-1 litres and 10.4+/-1.5 litres in groups A and B respectively. One hundred and eight patients were in group A while thirty one patients were in group B respectively. Both groups received albumin at a dose of 4 grams per litre of ascitic fluid removed. Mean age in both groups were 53 years. Hepatitis C was the commonest etiology in both the groups, followed by Hepatitis B. More than 70% patients in both the groups were in child class C. Serum creatinine at baseline and one week post LVP was 1.04+/-0.24 mg/dl and 1.07+/-0.35 mg/dl in GROUP A while 1.11+/-0.23 mg/dl and 1.41+/-0.94 mg/dl in GROUP B. [P value 0.35]. Similarly, serum sodium at baseline and one week post LVP was 130 +/-5.6 meq/lit and 129.6+/-5.9 meq/lit in GROUP A while 127.6+/-5.8 meq/lit and 128+/-6.2 meq/lit in GROUP B respectively. [P value 0.14] Conclusion: This study suggests that 4 grams of albumin per litre of ascitic fluid drained is effective in preventing the PICD related renal impairment following large volume paracentesis in cirrhosis

pattern of unplanned returns to emergency department

Unplanned returns are considered as one of the quality indicators of Emergency Department services. Studying characteristics of these unplanned returns may help to improve the services delivered by Emergency Department. To determine the rate of unplanned returns to Emergency Department, the most common complaint, the diagnosis and the consistency of diagnosis on the second visit compared to the initial visit. Emergency Department, BDF hospital, Bahrain. Descriptive cross-sectional study. One hundred and fifty-five participants were chosen at random from patients visiting the Emergency Department within 72 hours of their initial visit over 3 months period. Personal characteristics of the participants, the triage details of the first and second visits, most common complaints and diagnoses were reviewed. Six hundred ninety-one [4.6%] patients had unplanned returns within 72 hours of total visits to the Emergency Department. Three [1.9%] patients were admitted on the first visit and 40 [25.8%] upon the second visit. The most common complaints to revisit the Emergency Department were abdominal pain, 46 [29.7%] and chest pain and shortness of breath [SOB], 30 [19.4%]. The most common diagnoses were gastrointestinal conditions, chest conditions and trauma 35 [22.6%], 27 [17.4%] and 19 [12.3%] respectively. The majority of complaints and diagnoses 122 [78.7%] were consistent in the two visits. Unplanned returns to the Emergency Department constitute a fair proportion of total visits. Considering the characteristics of unplanned returns, it is important if specific Emergency Department populations are targeted in order to decrease unplanned returns

Physico-chemical standardization of Tukhm-e-qurtum [Carthamus tinctorius Linn]

Carthamus tinctorius, Linn. [Qurtum] of the family Compositae, is an annual plant which grows in tropical and sub-tropical parts of India. The seeds of the taxon are extensively used in Unani system of medicine as anti-inflammatory, antiasthmatic, aphrodisiac, blood purifier, carminative, diuretic, emmenagogue, expectorant, hepatoprotective, lithotryptic, liver tonic, purgative, sex stimulant, spermatogenic and tonic. In view of the medicinal value of this plant as described in Unani literature, the present study has been designed to set the physico-chemical standards of the seeds of Carthamus tinctorius, Linn. evolving some important parameters such as extractive value in different solvents, alcohol and water soluble contents, moisture contents, total ash value, water soluble ash value, acid insoluble ash value, bulk density, pH, chemical reactions, fluorescence analysis and thin layer chromatography. These parameters shall be valuable in quality control and identification of the drug

Perforated meckelts diverticulum in 55 years old lady: a case report

Meckel's diverticulum is the most common congenital abnormality of the gastrointestinal tract, it is often difficult to diagnose. It may remain completely asymptomatic, or mimic disorders such as Crohn's disease, appendicitis and peptic ulcer disease. Ectopic tissue, found in approximately 50 percent of cases and consists of gastric tissue in 60 to 85 percent and pancreatic tissue in 5 to 16 percent. Patients with perforation of Meckel's diverticulum may present with right iliac fossa pain, which mimics acute appendicitis or with generalised abdominal pain of acute abdomen as in peritonitis. Major complications include bleeding, obstruction, intussusception, diverticulitis and perforation. Management is by surgery as discussed in the present text

Ibn Sina The Prince of Physicians

Abu Ali al-Husain Ibn Abdullah Ibn Sina who has been called the 'Prince of Physicians', is known as Avicenna in the West. He was born in the village Afshana near Khorasan in Iran in August, 980 A.D. [Safar 370 H] and brought as a child to Bukhara where he received his earliest education under the direction of his father who was a high official. With an exceptional memory he had memorized the Qur'an and much Arabic poetry by the age of 10 years. Thereafter, he studied logic and metaphysics under teachers whom he soon outgrew and then spent the few years until he reached the age of 18 years in his own self education. He read avidly and mastered Islamic law, then medicine and finally metaphysics. He became court physician at the age of 18 years. He is supposed to have written 105 works upon a great variety of subjects in Arabic and Persian. The collection of his original observations intended as an appendix to the theoretical works, was unfortunately lost even before publication. He particularly contributed in the field of Aristotelian philosophy and medicine. He composed the Kitab ash-Shifa [Book of Healing], a vast philosophical and scientific encyclopedia, and Al-Qanoon Fi al-Tibb [The Canon of Medicine] which is among the most famous books in the history of medicine in both East and West. It was a compilation of his experiences in the practice of medicine and a compendium of all that was known about medicine at that time. It became the medical authority for several centuries and used at many medical schools as late as 1650 and reputedly is still used in the East. There is a need to evaluate the works done by Ibn Sina for further development of Unani medicine. Therefore, present paper is aimed at discussing the life of Ibn Sina and his contribution to medicine and related fields. The details are discussed in full length paper.

Epidemiological of oral squamous cell carcinoma and salivary gland tumors using international classification of diseases for oncology (a cross-sectional study in Baghdad during the period 1999-2006)

Oral cancer is one of the most debilitating and disfiguring of all malignancies, it is the sixth most frequently occurring cancer, with 274,000 new cases in 2002 worldwide. Two - thirds of them occurring in men. a descriptive cross-sectional study was executed on a sample of 877 of oral squamous cell carcinoma and salivary gland tumors. The data was collected from the medical records of 5 centers in Baghdad [College of Dentistry, University of Baghdad, Department of Oral Pathology, Specialized Surgical Teaching Hospital; Teaching Laboratories; Al-Wasity Hospital and the Nuclear Medicine and Radiation Hospital]. The diagnosis of individual tumor was based on the World Health Organization latest version of International Classification of Diseases for Oncology [10[th] revision]. The selected tumors were analyzed according to patient's identifying information [age, gender, occupation, address, cancer family history and smoking habit] and tumor site. A total of 877 cases were analyzed [479 male and 398 female with male to female ratio 1.2:1]. The tongue was the most commonly affected site [27.6%], followed by salivary glands [17.1%] and buccal mucosa of cheek [14.7%], The peak onset of selected tumors seen in age group between 40-64 years old [54.3%]. The male was affected more than female and the tongue was the most commonly affected site

Pleuro pericardial cyst

68-year-old male, presented with exertional dyspnoea and chest pain in his anterior chest wall for 3 months. He had no previous history of cardiac disease. Clinical examination failed to show anything significant. Chest X-ray showed a mass superimposed over the upper cardiac silhouette. He was further evaluated by chest CT, which showed a cystic mass in the anterior mediastinum measuring 9 x 7 cm in its maximum diameter. On surgical excision and histopathological examination, findings were consistent with benign pleuropericardial cyst, confirming the earlier diagnosis

Physico-chemical standardization of seeds of kaknaj [Physalis alkekengi Linn]

Physalis alkekengi Linn. [Kaknaj] of the family Solanaceae, is a diffuse perennial herb about 80 cm [32 inches] in height. The fruits are reddish or orange red in colour, fully covered in a thin sheath of membrane giving it a shape of urinary bladder and contain large number of flattened reniform seeds of light brown colour. The fruits are extensively used in Unani System of Medicine as anaesthetic, anthelmintic, anti-inflammatory, cicatrizant, contraceptive, diuretic, haemostyptic, hepatoprotective, lithotriptic and nephroprotective. In view of the medicinal value of this plant as described in Unani literature, the present study has been designed to set the physico-chemical standards of the fruits of Physalis alkekengi Linn, evolving some important parameters such as extractive value in different solvents, alcohol and water soluble contents, moisture contents, total ash value, water soluble ash value, acid insoluble ash value, bulk density, pH, chemical reactions, fluorescence analysis and thin layer chromatography. These parameters will prove to be instrumental in quality control and identification of the drug

Efficacy of Habb-e-Shifa as pre-anaesthetic medication

This randomized, placebo controlled double blind study was conducted on 100 female patients undergoing open cholecystectomy under general anaesthesia. The patients received either oral Habb-e-Shifa or placebo for seven pre-operative days. Habb-e-Shifa was found to increase duration of sleep and reduced rate pressure, product pre-operatively. The drug reduced oral secretions during extubation of the trachea. Post operative analgesic requirement was significantly reduced

Isolated tuberculosis thyroiditis as solitary thyroid nodule

Isolated involvement of the thyroid by tuberculosis is very rare as reported in literature. We are presenting a case of isolated tuberculous thyroiditis presented as a solitary thyroid nodule. The patient was treated with anti-tuberculous regimen and he responded well with disappearance of the nodule and normalization of the thyroid scan