Perfil dos atendimentos do serviço de atendimento móvel de urgência no município de Gurupi, Tocantins / Profile of mobile emergency service services in the municipality of Gurupi, Tocantins / Perfil de los servicios de urgencia móvil en el municipio de Gurupi, Tocantinas

O estudo objetivou descrever o perfil dos atendimentos realizados pelo SAMU-192 do município de Gurupi-TO. Estudo documental, epidemiológico, exploratório, transversal, retrospectivo e descritivo, com abordagem quantitativa. A amostra estratificada foi de 881 boletins de atendimentos do SAMU-192, referente ao período de janeiro a junho de 2022. A análise foi feita através do programa Microsoft Excel. Os usuários atendidos foram constituídos pelo sexo masculino (54,48%) com média de idade de 45,7 anos e idosos (31,1%). A maior parte das ocorrências foi de natureza clínica (61,6%) e traumática (24,1%). Quanto aos bairros que mais solicitaram o SAMU-192 foram o centro e o São José. A maioria dos atendimentos foi realizado pela Unidade de Suporte Básico (84%) e nos turnos da manhã (31,7%) e noite (26,1%). Tiveram como principal desfecho o atendimento no local e remoção dos usuários para um serviço de saúde (88%), sendo a UPA (67,5%) o principal destino. Destacam-se a descompensação de doenças crônicas, principalmente HAS e DM, como razão de demandas sucessivas que utilizam o SAMU-192. Caso essas enfermidades não sejam controladas na Atenção Primária em Saúde (APS) poderão acarretar complicações e incapacidades, demandando cada vez mais os serviços do SAMU.

The study aimed to describe the profile of the care provided by SAMU- 192 of the municipality of Gurupi-TO. Documentary, epidemiological, exploratory, cross-sectional, retrospective and descriptive study with quantitative approach. The stratified sample was 881 bulletins of the SAMU-192, referring to the period from January to June 2022. The analysis was done through the Microsoft Excel program. The users attended were male (54.48%) with average age of 45.7 years and elderly (31.1%). The majority of the occurrences were of a clinical nature (61.6%) and traumatic (24.1%). As for the neighborhoods that most requested the SAMU-192 were the center and the São José. The majority of services were provided by the Basic Support Unit (84%) and in the morning (31.7%) and evening (26.1%) shifts. The main outcome was on-site care and removal of users to a health service (88%), with the UPA (67.5%) being the main destination. Among the highlights are the decompensation of chronic diseases, mainly HAS and DM, as a reason for successive demands that use SAMU-192. If these diseases are not controlled in Primary Health Care (PHC), they may lead to complications and disabilities, increasingly requiring the services of SAMU.

El estudio tenía por objeto describir el perfil de las visitas realizadas por SAMU-192 en el municipio de Gurupi-TO. Estudio documental, epidemiológico, exploratorio, transverso, retrospectivo y descriptivo con enfoque cuantitativo. La muestra estratificada fue de 881 boletines de servicio del SAMU-192, referidos al período comprendido entre enero y junio de 2022. El análisis se realizó a través del programa Microsoft Excel. Los usuarios atendidos fueron varones (54,48%) con una edad media de 45,7 años y ancianos (31,1%). La mayoría de los casos fueron de naturaleza clínica (61,6%) y traumática (24,1%). En cuanto a los distritos que más solicitaron SAMU-192, estaban en el centro y en São José. La mayoría de las visitas se realizaron por la Dependencia de Apoyo Básico (84%) y por turnos de mañana (31,7%) y de tarde (26,1%). El principal resultado fue la atención in situ y la eliminación de usuarios para un servicio de salud (88%), siendo la UPA (67,5%) el destino principal. La clara compensación por las enfermedades crónicas, principalmente las abejas y el DM, se destaca como razón de las sucesivas demandas que utilizan el SAMU-192. Si estas enfermedades no están controladas en la Atención Primaria de Salud (APS), pueden llevar a complicaciones y discapacidades, exigiendo cada vez más los servicios de SAMU.

Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection

INTRODUCTION: The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). METHODS: Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). A healthy control group was investigated and consisted of 299 HCV- and HBV-seronegative individuals. RESULTS: No significant differences in allele, genotype and haplotype frequencies were observed between the investigated groups, and no association was observed between the polymorphisms and histopathological results. Nevertheless, genotypes TA/AA (rs5743305) and GG (rs3775291) appear to be associated with higher levels of ALT (p<0.01), AST (p<0.05) and PT (p<0.05). In addition, genotypes TT (rs5743305; p<0.05) and GG (rs3775291; p<0.05) were associated with higher GGT levels. CONCLUSIONS: This genetic analysis revealed the absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection. .

Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin

Introduction This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results There was no amplification of either gag or pol segments from XRMV in any of the samples examined. Conclusions This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases. .