Serological follow up of positive SARS-CoV-2 cases / Seguimiento serológico de casos positivos a SARS-CoV-2

Abstract: Objective: To describe the humoral response in a cohort with mild and asymptomatic SARS-CoV-2 infection previously identified in a community-based serological survey. Materials and methods: This study was an observational follow up of 193 subjects previously identified with positive anti-SARS-CoV-2 antibodies invited for a second test 112 days after the first sampling. All completed a standardized electronic questionnaire. IgM/IgG antibodies were determined using a qualitative IgM/IgG chemiluminescent immunoassay. Results: Among the 193 eligible subjects, a total of 174 (90%) attended the follow-up visit, and their serum samples were tested. Of the samples, 171 (98.3%) were still positive, and 3 (1.7%) were negative. Also, the cut-off index (COI) value of the immunoassay significantly increased from the first to the second test (P <0.001). Conclusions: Our findings support a sustained humoral response in individuals with mild and asymptomatic SARS-CoV-2 infection up to 112 days after a positive serologic baseline test, accompanied by increasing antibody titers.

Resumen: Objetivo: Describir la respuesta humoral en una cohorte con una infección leve o asintomática por SARS-CoV-2, previamente identificada en una encuesta serológica comunitaria. Material y métodos: Se realizó un seguimiento observacional de 193 individuos previamente identificados con anticuerpos IgM/IgG anti-SARS-CoV-2 invitados 112 días después de una determinación serológica inicial. Todos los participantes completaron un cuestionario electrónico estandarizado. Se determinaron los anticuerpos IgM/IgG mediante un inmunoensayo quimioluminiscente cualitativo. Resultados: De entre los 193 sujetos elegibles, 174 (90%) acudieron al seguimiento. De las muestras, 171 (98.3%) eran positivas y 3 (1.7%) negativas. Además, el valor de COI del inmunoenasayo se incrementó al comparar la primera y segunda determinación (P <0.001). Conclusiones: Los presentes resultados apoyan una respuesta humoral sostenida en individuos con infección por SARS-CoV-2 con síntomas leves o asintomática hasta 112 días después de una prueba serológica positiva, acompañada de incremento en los títulos de anticuerpos.

Arterial thrombosis and intracardiac thrombus as the initial presentation of a recurrent paraganglioma: case report and review of the literature

SUMMARY Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that result in the uncontrolled release of catecholamines and secondary hypertension. They usually manifest with episodic blood pressure fluctuations, headaches and palpitations. In some cases PPGLs may be asymptomatic until they are detected as a diagnostic approach to other diseases. There have been reports that have associated PPGLs with arterial thrombosis, some with the additional finding of intracardiac thrombi. We present the case of a 21-year-old male Hispanic patient with a recurrent para-aortic paraganglioma detected by persistent hypertension, bilateral lower limb artery thrombosis and an intracardiac thrombus.

Global longitudinal strain as a biomarker in diabetic cardiomyopathy. A comparative study with Gal-3 in patients with preserved ejection fraction / Deformación longitudinal global como un biomarcador en miocardiopatía diabética. Estudio comparativo con galectina-3 en pacientes con fracción de eyección preservada

Abstract: Objectives: To establish a relationship between global longitudinal strain (GLS) and Galectin-3 in pre-clinical heart failure in diabetic patients. Galectin-3 is a biomarker in heart failure with depressed ejection fraction (HFdEF). The hypothesis is presented that Galectin-3 is related to GLS and can detect left ventricular dysfunction in heart failure with preserved ejection fraction. Methods: Galectin-3 and GLS were measured in 121 asymptomatic individuals: 14 diabetics with mild depressed ejection fraction (mdEF) (LVEF 47.0 ± 6.9); 76 diabetics with preserved ejection fraction (LVEF 61 ± 5.5), and 31 controls (61.7 ± 5.1). Results: Galectin-3 was elevated in all diabetics vs controls (3.46 ± 1.36 ng/ml vs 2.78 ± 0.91 ng/ml; p = .003). It was also elevated in mdEF (3.76 ± 1.12 ng/ml vs 2.78 ± 0.9 ng/ml; p = .009) and pEF subjects (3.41 ± 1.40 ng/ml vs 2.78 ± 0.9 ng/ml; p = .058), respectively, vs controls. No difference in Gal-3 was found between diabetic groups (p = .603). Diabetics had lower GLS than controls (-18.5 ± 3.9 vs -20 ± 2.6; p = .022). Diabetics with mdEF had lower GLS than those with pEF (-13.3 ± 3.41 vs -19 ± 3.2; P<.001). There was no difference in GLS with pEF compared to controls (-19.4 ± 3.2 vs -20 ± 2.6; p = .70). Conclusions: Galectin-3 is elevated in diabetic patients with mdEF, and is associated with a diminished GLS. GLS could be an early marker of left ventricular dysfunction as well as evidence of diabetic cardiomyopathy.

Resumen: Objetivos: Establecer una asociación entre deformación longitudinal global (DLG) y galectina-3 en insuficiencia cardiaca preclínica en pacientes diabéticos. Galectina-3 es un biomarcador en insuficiencia cardiaca con fracción de eyección deprimida. Nuestra hipótesis es que la DLG y galectina-3 correlacionan y pueden detectar disfunción ventricular en insuficiencia cardiaca con FEVI preservada. Métodos: Se midieron galectina-3 y DLG en 121 individuos asintomáticos: 14 diabéticos con FEVI deprimida leve (FEdl) (FEVI 47 ± 6.9); 76 diabéticos con FEVI preservada (FEp) (FEVI 61 ± 5.5) y 31 sujetos controles (FEVI 61.7 ± 5.1). Resultados: Galectina-3 se encontró elevada en todos los diabéticos vs controles (3.46 ± 1.36 ng/ml vs 2.78 ± 0.91 ng/ml; p = 0.003). Está elevada en sujetos con FEdl (3.76 ± 1.12 vs 2.78 ± 0.9 vs ng/ml p = 0.009) y FEp (3.41 ± 1.40 vs 2.78 ± 0.9 ng/ml p = 0.058), respectivamente vs controles; no encontramos diferencia en galectina-3 en ambos grupos de diabéticos (p = 0.603). Los diabéticos tienen menor DLG que los controles (-18.5 ± 3.9 vs -20 ± 2.6; p = 0.022). Los diabéticos con FEdl tienen DLG más disminuida que aquellos con FEp (-13.3 ± 3.41 vs -19 ± 3.2; p < 0.001). No existe diferencia en DLG con FEp y controles (-19.4 ± 3.2 vs -20 ± 2.6; p = 0.70). Conclusiones: Galectina-3 está elevada en diabéticos con FEdl y correlaciona DLG disminuida. DLG podría ser un marcador temprano de disfunción ventricular y evidencia en miocardiopatía diabética.

Educación, actividad física y obesidad en adultos con diabetes tipo 2 desde la perspectiva del autocuidado de Orem / Education, Physical Activity and Obesity among Adults with Type II Diabetes from the Standpoint of Orem's Self-care Theory / Educação, atividade física e obesidade em adultos com diabete tipo 2 a partir da perspectiva do autocuidado de Orem

Objetivos: describir la relación de la actividad física (pasos/día)/ejercicio con la obesidad (índice de masa corporal, circunferencia de cintura y grasa corporal) en adultos con diabetes tipo 2. Se planteó además: 1) determinar la relación de la educación/comprensión en diabetes con la actividad física/ejercicio, y 2) establecer diferencias de actividad física/ejercicio y obesidad/sobrepeso de acuerdo con variables sociodemográficas. Materiales y métodos: diseño descriptivo correlacional, muestra aleatoria de 124 pacientes de 17 centros comunitarios de Tampico, Tamaulipas, México. Las mediciones incluyeron: podómetro New-Life Style 2000, cuestionarios de autocuidado y Perfil de Cuidado en Diabetes, IMC, CC y grasa corporal. Los datos se analizaron con medidas de tendencia central, correlación de Spearman, prueba U de Mann-Whitney y Kruskal Wallis. Resultados: el promedio de pasos/día mostró relación inversa con el IMC (r s = - 0,282, p < 0,01) y la CC (r s = - 0,300, p < 0,01). La comprensión en diabetes tuvo relación positiva con el ejercicio (r s = 0,179, p = 0,04). Las mujeres fueron quienes tuvieron mayor porcentaje de grasa corporal (p < 0,05). Conclusiones: los hallazgos tienen implicaciones importantes para el ejercicio práctico de la profesión de enfermería que juega un papel esencial en el fomento de la actividad física y otros comportamientos básicos de autocuidado a través de la educación. La educación basada en teoría se hace necesaria para el avance en el conocimiento de la disciplina.

Objectives: Describe the relationship between physical activity (steps/day)/exercise and obesity (body mass index, waist circumference and body fat) in adults with type II diabetes. The study also was intended to: 1) determine the relationship between education/ understanding of diabetes and physical activity / exercise, and 2) to identify differences in physical activity / exercise and overweight / obesity according to a set of socio-demographic variables. Materials and methods: The study was descriptive and correlational in design, with a random sample of 124 patients from 17 community centers in Tampico, Tamaulipas, Mexico. The measurements include: the New Lifestyles 2000 pedometer, plus questionnaires on self-care and the Diabetes Care Profile, BMI, WC and body fat. The data were analyzed with measures of central tendency, the Spearman correlation, the Mann- Whitney U testand the Kruskal Wallis test. Results: The average number of steps / day showed an inverse relationship to the BMI (r s = - 0.282, p < 0.01) and WC (r s = - 0.300, p < 0.01). Understanding diabetes had a positive relationship to exercise (r s = 0.179, p = 0.04). Those with a higher percentage of body fat were women (p < 0.05). Conclusions: The findings have important implications for professional nursing practice, which plays a crucial role in promoting physical activity and other self-care behavior through education. Theory-based education is necessary for the advancement of knowledge in the discipline.

Objetivos: descrever a relação da atividade física (passos/dia)/exercício com a obesidade (índice de massa corporal, circunferência de cintura e gordura corporal) em adultos com diabete tipo 2. Além disso, propôs-se: 1) determinar a relação da educação/compreensão em diabete com a atividade física/exercício, e 2) estabelecer diferenças de atividade física/exercício e obesidade/excesso de peso de acordo com variáveis sociodemográficas. Materiais e métodos: desenho descritivo correlacional, amostra aleatória de 124 pacientes de 17 centros comunitários de Tampico, Tamaulipas, México. As medições incluíram: pedômetro New-Life Style 2000, questionários de autocuidado e Perfil de Cuidado em Diabete, IMC, CC e gordura corporal. Os dados foram analisados com medidas de tendência central, correlação de Spearman, prova U de Mann-Whitney e Kruskal Wallis. Resultados: a média de passos/dia mostrou relação inversa com o IMC (r s = - 0,282, p < 0,01) e a CC (r s = - 0,300, p < 0,01). A compreensão em diabete teve relação positiva com o exercício (r s = 0,179, p = 0,04). As mulheres foram as que tiveram maior porcentagem de gordura corporal (p < 0,05). Conclusões: as descobertas têm implicações importantes para o exercício prático da profissão de enfermagem que desenvolve papel essencial no fomento da atividade física e outros comportamentos básicos de autocuidado por meio da educação. A educação baseada em teoria se faz necessária para o avanço no conhecimento da disciplina.

Hemoglobin A1c: a reliable and accurate test for diabetes care? A prospective study in Mexico / Hemoglobina A1c: ¿una prueba precisa y confiable para el cuidado de la diabetes ? Estudio prospectivo en México

Objective. To compare the concordance correlation coefficient for HbA1c results in an in-field experience. Materials and methods. A prospective study in Monterrey, Mexico from April to August 2012 was conducted to evaluate the day-to-day clinical situation when measuring HbA1c. Blood samples from 38 consecutive patients were sent to seven local laboratories and one international reference laboratory. Results. Poor concordance was found in 4 out of 7 laboratories, moderate in 2 out of 7, and significant in just one. HbA1c values from three laboratories fluctuated more than 1% above or below the reference laboratory in more than 30% of cases, and more than 2% in 10%-20% of subjects. Conclusions. Standardized HbA1c measurement has not occurred worldwide. Physicians should be aware of this issue and be cautious of HbA1c guidelines on diabetes diagnosis or management until proper standardization programs are implemented.

Objetivo. Comparar el coeficiente de correlación de concordancia de HbA1c. Material y métodos. Estudio prospectivo en Monterrey, México, de abril a agosto de 2012 para evaluar la medición de la HbA1c. Participaron 38 individuos y se envió la muestra a 7 laboratorios locales y a uno internacional de referencia. Resultados. Se encontró pobre concordancia en 4 de 7 laboratorios, moderada en 2 y una concordancia significativa en uno. Los valores de HbA1c de tres laboratorios fluctuaron más de 1% del laboratorio de referencia en más de 30% de los casos y más de 2% en 10 a 20%. Conclusiones. La estandarización de la HbA1c no está concluida. Los médicos deberían tomar con cautela las recomendaciones de las guías para HbA1c en el diagnóstico o manejo de la diabetes hasta que se implementen los programas de estandarización.

Self-Care Behaviors and Health Indicators in Adults with Type 2 Diabetes / Condutas de autocuidado e indicadores de saúde em adultos com diabetes tipo 2 / Conductas de autocuidado e indicadores de salud en adultos con diabetes tipo 2

This descriptive correlational study aimed to analyze self-care behaviors and their relationship with health indicators represented by glycemic control, lipid profile, Body Mass Index [BMI], waist circumference and body fat percentage in a sample of 98 adults with type 2 diabetes in an area of Nuevo Leon, Mexico (August 2005/May 2006). The results showed a low self-care behaviors index (X > or = 36.94, SD=15.14). A significant relationship was found between self-care behaviors and glycosilated hemoglobin [HbA1c] (r s=-.379, p<.001), triglycerides (r s=-.208, p=.040), BMI (r s=-.248, p=.014) and body fat percentage (r s=-.221, p=.029). Multivariate analysis revealed the influence of self-care behaviors on HbA1c, BMI and body fat percentage with explained variances of 9 to 41 percent (p < .05). From all self-care dimensions, diet was the most predictive for health indicators, moderated by gender and understanding of diabetes contents (p< .05).

Estudo descritivo correlacional que teve como objetivo analisar as condutas de autocuidado e a sua relação com indicadores de saúde, representados pelo controle glicêmico, perfil de lipídios, índice de massa corpórea (IMC), circunferência da cintura e porcentagem de gordura corporal, em amostra aleatória de 98 adultos com diabetes tipo 2, de uma zona conturbada em Nuevo León, México (agosto 2005/maio 2006). Os resultados mostraram índice de autocuidado baixo (X > ou = 36,94, dp=15,14). Encontrou-se correlação significativa entre o autocuidado e a hemoglobina glicolisada (HbA1c) (r s=0,379, p<0,001), triglicerídeos (r s=0,208, p=0,040), IMC (r s=0,248, p=0,014) e gordura corporal (r s=0,221, p=0,029). A análise multivariada revelou influência do autocuidado em HbA1c, IMC e gordura corporal com variâncias explicadas de 9 a 41 por cento (p<0,05). Das dimensões do autocuidado, a dieta foi o principal fator de predição moderado pelo gênero e a compreensão dos conceitos sobre o diabetes (p<0,05).

Se trata de un estudio descriptivo y correlacional que tuvo como objetivo analizar las conductas de autocuidado y su relación con indicadores de salud, representados por el control de la glucemia, perfil de lípidos, IMC, circunferencia de cintura y porcentaje de grasa corporal, en una muestra aleatoria de 98 adultos con diabetes tipo 2 de un zona periférica de la ciudad de Nuevo León, en México; los datos fueron recolectados entre agosto del 2005 y mayo del 2006. Los resultados mostraron un índice de autocuidado bajo (promedio= 36,94 y desvío estándar=15,14). Se encontró correlación significativa entre el autocuidado y la HbA1c (r s= 0,379, p< 0,001), triglicéridos (r s= 0,208, p=0,040), IMC (r s= -.248, p=0,014) y grasa corporal (r s= 0,221, p=0,029). El análisis multivariado reveló influencia del autocuidado en HbA1c, IMC y grasa corporal con varianzas explicadas de 9 por ciento a 41 por ciento (p <0,05). De los factores del autocuidado, la dieta fue el principal factor de predicción moderado por el género y la comprensión de los aspectos de la diabetes (p<0,05).