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1.
Rev. méd. Chile ; 127(4): 444-50, abr. 1999. tab, graf
Artigo em Espanhol | LILACS | ID: lil-243915

RESUMO

Background: Central nervous system damage associated to HTLV-I does not limit itself to the spinal cord, but also involves subcortical structures, producing cognitive impairment and behavioral changes which eventually could conform a new form of subcortical dementia. Aim: To study cognitive changes in patients with HTLV-I associated myelopathy. Patients and methods: Forty three patients (31 female) with Tropical Spastic Paraparesis, aged 52 years old as a mean and with a disease lasting a mean of 7.5 years, were studied. The diagnosis was based on clinical, radiological and neurophysiological changes. The virus was identified with ELISA, indirect immunofluorecence, Western Blot or proviral DNA identification. Cognitive assessment was done using the Wechler Adult Intelligence Scale (WAIS) and Benton Visual Retention Test (form D). Patients were grouped according to their motor disability in; 23 patients with independent spastic gait, 11 patients that needed support to walk and 9 patients unable to walk. Results: WAIS test demonstrated cognitive impairment with special deficit in some subtests such as Digit Span, Digit Symbol, Picture Arrangement and Object Assembly. Benton Test also disclosed cognitive impairment. There was a positive relationship between cognitive and motor performance. Conclusions: At least 50 percent of patients with Tropical Spastic Paraparesis have certain degree of intellectual and affective impairment


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Demência/etiologia , Paraparesia Espástica Tropical/complicações , Atrofia Muscular/etiologia , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Marcha , Testes de Inteligência , Paraparesia Espástica Tropical/etiologia , Paraparesia Espástica Tropical/psicologia , Testes Neuropsicológicos
2.
Rev. méd. Chile ; 125(2): 209-13, feb. 1997. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-194820

RESUMO

We report a 45 years old female with HTLV-I associated myelopathy, followed up for 10 years who, 5 years ago, developed personality changes and intellectual deterioration, assessed with the Wais-Benton test. She also had alterations in the electroencephalogram and a nuclear magnetic resonance imaging of the brain showed hypodensity in T1 and hyperdensity in T2 subcortical regions. The progression of intellectual impairement was related to an increase in proviral DNA, assessed with polymerase chain reaction


Assuntos
Humanos , Feminino , Adulto , Vírus Linfotrópico T Tipo 1 Humano/patogenicidade , Paraparesia Espástica Tropical/diagnóstico , Reação em Cadeia da Polimerase , Encefalite Viral/diagnóstico , Demência/etiologia , Paraparesia Espástica Tropical/complicações
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