Digital subtraction radiographic analysis of the combination of bioabsorbable membrane and bovine morphogenetic protein pool in human periodontal infrabony defects

OBJECTIVES: This study assessed the bone density gain and its relationship with the periodontal clinical parameters in a case series of a regenerative therapy procedure. MATERIAL AND METHODS: Using a split-mouth study design, 10 pairs of infrabony defects from 15 patients were treated with a pool of bovine bone morphogenetic proteins associated with collagen membrane (test sites) or collagen membrane only (control sites). The periodontal healing was clinically and radiographically monitored for six months. Standardized pre-surgical and 6-month postoperative radiographs were digitized for digital subtraction analysis, which showed relative bone density gain in both groups of 0.034 ± 0.423 and 0.105 ± 0.423 in the test and control group, respectively (p>0.05). RESULTS: As regards the area size of bone density change, the influence of the therapy was detected in 2.5 mm² in the test group and 2 mm² in the control group (p>0.05). Additionally, no correlation was observed between the favorable clinical results and the bone density gain measured by digital subtraction radiography (p>0.05). CONCLUSIONS: The findings of this study suggest that the clinical benefit of the regenerative therapy observed did not come with significant bone density gains. Long-term evaluation may lead to a different conclusions.

Avaliação clínica comparativa da sintomatologia após a realização de enxertos gengivais livres autógenos e alógenos para a criação e manutenção de uma faixa de mucosa ceratinizada / Comparative clinical evaluation of postoperative morbidity after autogenous free gingival graft and dermal matrix allograft to gain and maintain keratinized tissue

Avaliou-se comparativamente os sinais e sintomas pós-operatórios de enxertos gengivais livres (EGL) e de matriz dérmica acelular (MDA) em 22 pacientes que possuíam duas áreas com quantidade inadequada de mucosa ceratinizada na região de pré-molares inferiores de arcos homólogos, sendo que cada paciente foi submetido aos dois tipos de enxertos. A análise foi realizada por meio de respostas a um questionário de sinais e sintomas no pós-operatório imediato de 10 dias. Os resultados foram analisados estatisticamente pelo teste de McNemar, p < 0,05, para comparar as frequências relativas de cada ocorrência (dor, edema e sangramento) e também para analisar o sítio de escolha do paciente de maior sensibilidade dolorosa, demonstrando similaridade de sintomatologia nos sítios enxertados e eleição da área doadora de enxerto autógeno como a mais sensível. Com base nesses resultados pode-se concluir que a MDA quando utilizada como substituta dos EGL apresenta menor desconforto no pós-operatório por não necessitar de uma área cirúrgica adicional para remoção de tecido.

This clinical study compared the postoperative morbidity resulting of free gingival graft and acellular dermal matrix allografts. Twenty two patients with contralateral insufficient keratinized tissue were submitted to both grafts and answered a signals and symptoms questionnaire in the 10th immediate postoperative day. McNemar test, p < 0,05, was used to compare the relative frequency of pain, swelling, bleeding and to analyze the most sensible area in accordance with the patients. The postoperative sensibility of the receptor area was comparable in both groups and the donor area of free gingival graft was the most sensible. The results of this study suggest that acellular dermal matrix allografts can be used as free gingival graft substitute with less postoperative discomfort and it’s not necessary any additional site to remove autogenous tissue.