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Acta Physiologica Sinica ; (6): 551-558, 2020.
Artigo em Chinês | WPRIM | ID: wpr-878200

RESUMO

The purpose of the present study was to determine the effects of resveratrol on hypoxia-induced oxidative stress and proliferation in pulmonary artery smooth muscle cells (PASMCs) and the underlying mechanism. Primary rat PASMCs were isolated and cultured in vitro and pretreated with different concentrations of resveratrol (10, 20, and 40 µmol/L) or the NADPH oxidase (NOX) inhibitor VAS2870 (10 µmol/L) for 0.5 h. The cells were then cultured under normoxia (21% O


Assuntos
Animais , Ratos , Proliferação de Células , Células Cultivadas , Hipóxia , Miócitos de Músculo Liso , NADPH Oxidase 4 , Estresse Oxidativo , Artéria Pulmonar , Espécies Reativas de Oxigênio , Resveratrol/farmacologia , Transdução de Sinais
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