1.
Chinese Pharmacological Bulletin
;
(12): 23-26, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-857388
RESUMO
In cardiac myocytes, Ca2+ sparks origining from a single RyR or a few RyRs are triggered by a single L-type Ca2+ channel or occur spontaneously. Ca2+ sparks constitute the elementary local Ca 2+ release events from the SR. Ca2+ sparks occur at Z-lines and randomly distribute at different locations, the characteristics of the kinetics are regulated by many factors. In addition, ICa.T, Na+/Ca2+ exchange, ICa (TTX) and IP3 are other putative sources of Ca2+ that trigger SR Ca2+ release.