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1.
Acta Pharmaceutica Sinica ; (12): 979-984, 2008.
Artigo em Chinês | WPRIM | ID: wpr-232656

RESUMO

The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.


Assuntos
Animais , Humanos , Apoptose , Benzimidazóis , Farmacologia , Catequina , Farmacologia , Linhagem Celular Tumoral , Neoplasias , Patologia , Piperazinas , Farmacologia , Inibidores de Proteínas Quinases , Farmacologia , Piridonas , Farmacologia , Pirimidinas , Farmacologia , Pirróis , Farmacologia , Receptor IGF Tipo 1 , Química , Metabolismo , Transdução de Sinais
2.
Acta Pharmaceutica Sinica ; (12): 354-358, 2004.
Artigo em Inglês | WPRIM | ID: wpr-302810

RESUMO

<p><b>AIM</b>Isolation and structural elucidation of the triterpenoid saponins of Oplopanax elatus Nakai.</p><p><b>METHODS</b>Solvent extraction and column chromatography were used to isolate the triterpenoid saponins, physico-chemical constants and spectroscopic analysis were employed for structural elucidation.</p><p><b>RESULTS</b>Four newtriterpenoid saponins named cirenshenoside S (1), cirenshenoside T (2), cirenshenoside U (3) and cirenshenoside V (4) were isolated, and their structures were elucidated to be 3-O-beta-D-glucopyranosyl 3beta,23-dihydroxylup-20 (29)-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl (1 --> 4)-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (1), 3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1 --> 4)-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (2), 3-O-beta-D-glucopyranosyl 3beta-hydroxyolean-9(11),12-dien-28-oic acid 28-O-alpha-L-rhamnopyranosyl (1 --> 4)-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (3) and 3alpha-hydroxyolean-12-dien-23,28-dioic acid 28-O-alpha-L-rhamnopyranosyl (1 --> 4 )-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranoside (4), respectively.</p><p><b>CONCLUSION</b>Compounds 1-4 are new triterpenoid saponins and isolated from the leaves of Oplopanax elatus Nakai for the first time.</p>


Assuntos
Conformação Molecular , Estrutura Molecular , Oplopanax , Química , Folhas de Planta , Química , Plantas Medicinais , Química , Saponinas , Química
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