Changes in muscle spindle afferent discharge activities in rat soleus following hindlimb immobilization / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the changes in the afferent discharge activities of the sensory nerve endings in muscle spindles of rats with hindlimb immobilization.</p><p><b>METHODS</b>Plaster cast was used immobilize the hindllimbs of rats. Using air-gap technique, the spontaneous discharge of the muscle spindles and its responses to perfusion with succinylcholine (0.05 mg/ml) and suspension in an extended position were observed in isolated muscle spindles from rats with hindlimb immobilization for 3, 7, and 14 days.</p><p><b>RESULTS</b>The muscle spindles of rat soleus showed a sharp decrease in spontaneous discharge frequency (P<0.01) and response to succinylcholine perfusion after 3 days of hindlimb immobilization (P<0.05). Significant changes of the firing rate in an extended position was observed in rats after a 14-day immobilization (P<0.01). The duration of individual spikes was significantly prolonged following hindlimb immobilization (P<0.01).</p><p><b>CONCLUSION</b>Muscle spindle discharges decrease significantly in rats following hindlimb immobilization, which might be related to reduced contractile properties of the muscle spindle.</p>

Clinical features of female patients with acute myocardial infarction and their outcomes / 中华老年心脑血管病杂志

Objective To assess the clinical features of female patients with AMI and their out-comes .Methods Two hundred and eighty-four AMI patients (216 males and 68 females) were in-cluded in this study .Their clinical features ,complications ,PCI and outcomes were comared .The patients were followed up for 3 months ,during which the major adverse cardiac events (MACE) were observed with their mortality and risk factors for MACE assessed .Results The age was ol-der and the heart rate ,TIMI grade ,GRACE score were significantly higher in female patients than in male patients (P<0 .05 ,P<0 .01) .The ratio of female patients who underwent PCI was signif-icantly lower than that of male patients who underwent PCI (30 .9% vs 48 .6% ,P=0 .012) .The in hospital mortality was higher in female patients than in male patients (17 .6% vs 9 .3% ,P=0.077) ,and the incidence of MACE in a 3-month follow-up period was significantly higher in fe-male patients than in male patients (27 .9% vs 15 .7% ,P=0.032) .Multivariate logistic regression analysis showed that age and Killip classification were the independent risk factors for in hospital mortality (OR=1 .078 ,95% CI:1 .035 -1 .123 ,P=0 .000 ;OR= 1 .901 ,95% CI:1 .373 -2 .633 , P=0 .000) and for MACE in a 3-month follow-up period (OR=1 .040 ,95% CI:1 .008 -1 .074 , P=0 .015;OR=1 .543 ,95% CI:1 .170-2 .034 ,P=0 .002) .PCI was a protective factor for MACE in a 3-month follow-up period (OR=0 .090 ,95% CI:0 .026-0 .306 ,P=0 .000) .Conclusion The age of female AMI patients is older and their heart function is poorer with a higher risk of MACE and a less chance for PCI .However ,gender itself is not an independent predictor for in hospital mortality and M ACE in a 3-month follow-up period .

POWER SPECTRUM ANALYSIS OF THE FINGER PLETHYSMOGRAM IN TWO KINDS OF PATIENTS WITH ABRUPT PULSE AND THE HEALTHY YOUNG WOMEN / 西安交通大学学报(医学版)

This article deals with the power spectrum analrsis of some healthy young women and some patients with abrupt pulse. It is found that in the healthy young women the spectra show that the most energy basically distributes within the range of 0～20 Hz this suggests that the blood current is relatively smooth. In the hyperthyroid patients it shows that within full range of 0～200 Hz widely distributes the energy and main part of which locates in the range of 0～20 Hz where the distibution of energy shows the phenomenon of early decline. This indicates that there is obvious increase of turbulenoe and decline in blood stability in patients 'vessds. The power spectrum in early pregnant women demonstrates that most part of energy distributes within the range of 0～20 Hz where the energy declines slowly. This is different from that of the hyperthyoid patients. Moreover, nearby 100 Hz there is often seen an obvious peak. These means that the blood stability in eraly pregnant women declines to some extent between above two ses. This article has provided a useful datum for researching the cause of formation of the pulse and studying the theory of pulse condition of the Traditional Chinese Medicine.

THE DRP EVOKED BY MUSCLE SPINDLE AFFERENTS AND ITS EFFECTS ON THE DRP VRP EVOKED BY STIMULATING N. PERONAEUS / 西安交通大学学报(医学版)

Using the bullforg and toad in experi ments, and making the dorsal root potential (DRP) and ventral rool potential (VRP) as the indexes of the presynaptic inhibition, we examined and analysed the central effects produced by the spindle a fferents during stretching muscle. The results indicat that, aftet muscle paralysis, the phase DRP recorded on dorsal root simultanesously with stretching M. Semitendinosus is produced by spindle afferents, so it is named spindle-DRP'. The characteristic of the spindle-DRP has been discussed in detail. Meanwhile it was found that continual spindle afferents could increase the DRP evoked by electro-stimulating N. peronaeus, can decrease the nerve VRP evoked in this way. These results suggest that the spindle afferents are involved in the acupuncture anaesthesia, perhaps through the presynaptic inhibition. This result may be a new data for the research of the theory of presynaptic inhibition and the principle of acupuncture anaesthesia.