Efficacy analysis of sequential surgery after the DCF scheme induction chemotherapy in T2-3 laryngeal carcinoma and hypopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To study clinical efficacy of surgery after the DCF induction chemotherapy in T2-3 laryngeal carcinoma and hypopharyngeal carcinoma.@*METHOD@#To analyze clinical data about 102 cases of T2-3 laryngeal carcinoma and hypopharyngeal carcinoma retrospectively, 62 cases were divided into experimental group and 40 cases in control group, the experimental group completed three cycles of the DCF induction chemotherapy, then the efficacy was evaluated, surgery were carried out in the end, the control group received operation directly. In two groups, tumor response rates, toxicities, positive surgical margin rates and survival rate differences were observed and compared.@*RESULT@#Tumor response rate was 61.3% in experimental group, the laryngeal carcinoma rate was significantly lower than that in hypopharyngeal (44.4% VS 84.6%, P 0.05). The foci edges of 0. 3 cm and 0. 5 cm positive margin rate of hypopharyngeal carcinoma in experimental group were significantly lower than in its control (P 0.05). During induction chemotherapy in the experimental group, no serious adverse reactions were found.@*CONCLUSION@#Induction chemotherapy of DCF regimen can not only narrow T2-3 laryngeal carcinoma and hypopharyngeal carcinoma' area, but also ensure an adequate safety margin.

Non-surgical treatment of hepatocellular carcinoma / 国际肿瘤学杂志

Treatment strategies of advanced hepatocellular carcinoma reduce pain,improve quality of life and prolong survival.The latest developments at home and abroad focus on a variety of topical treatments (endovascular treatment,a variety of ablation therapy,radiation therapy) combined with each other and also combined with targeted therapy.In addition,systemic chemotherapy,biological targeting therapy and traditional Chinese medicine have achieved some new progressions.

Changes of Serum Vascular Endothelial Growth Factor before and after Interventional Therapy and Their Clinical Significance in Patients with Hepatocellular Carcinoma / 医学研究杂志

Objective To study the changes of serum vascular endothelial growth factor(VEGF)levels before and after interventional therapy of hepatocellular carcinoma(HCC),in order to find out a experimental proof that can start the anti-angiogenesis therapy.Methods Enzyme linked immunosorbentassay(ELISA)was used to detect serum levels of VEGF before transcathter arterial chemo-ebolization and in 24 hours,72 hours,7 days,14 days,30 days,after the operation,in 50 healthy individuals and 54 HCC pationts.Results Serum levels of VEGF in 54 patients with HCC were significantly higher than those in healthy individuals(P