RESUMO
Post stroke depression has a huge impact on the rehabilitation and recurrence of patients with stroke.Its specific pathogenesis is unknown.Monoamine transmitters, inflammatory cytokines, hypothalamic pituitary adrenal axis function and neural plasticity are involved.Because of the uncertainty and side effects of drug therapy, non-drug therapy, especially behavioral intervention, is attracting more and more attention from clinicians.At present, behavioral intervention methods commonly used in clinical practice include: cognitive behavioral therapy, motivational interviewing, sports, music, and so on.Although a large number of clinical studies have shown that behavioral intervention has a clear therapeutic effect on post stroke depression, there is still no high level of recommendation for the prevention and treatment of post-stroke depression due to the lack of large sample and high quality multicenter randomized controlled studies.